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Showing posts with label inhaling. Show all posts
Showing posts with label inhaling. Show all posts

Wednesday, August 13, 2014

Iodize the Air


Here's an interesting idea! Iodize the air in order to protect the populace from contagious illnesses. 

Article Source: Sajou's Analytic Cyclopedia of Practical Medicine, Volume 10, published 1920.

Link

iodine crystals
The article discusses various means of treating the flu available at the time but I found the discussion on prophylaxis most interesting:)So interesting, in fact, that I iodized the air in my home. The images here are of iodine subliming. It was amazingly beautiful, the color is just magnificent! I did not have the correct apparatus though... I used a ceramic essential oil diffuser and the heat was too close... the air became iodized quite quickly. My eyes stung. Other than that no untoward effects. My home still smells of iodine. I like it :) Nag Champa or iodine, hmmmm... It's a toss-up!

Do I recommend that you try this at home? No...I'll try this again with perhaps tincture or a few drops of lugol's in water. Sublimating crystals, although beautiful, create a very strong vapor.

There are some gentler methods suggested in this post:

http://iodinehistory.blogspot.com/2012/06/inhalation-of-vapors-of-iodine.html 


...At the present writing (Autumn. 1920) there are suggestive indications that another paudemic will occur during the fall or winter...

...The fact that the pandemic of 1918 cost the world at least ten million lives prompts the question: Are we now better prepared to meet the issue? ...


iodine sublimation
...Yet, a query which is at once suggested is: Why does not influenza annihilate humanity under these conditions when the air is contaminated with its germs? Further personal studies then showed that we were protected to a degree estimated at from 60 to 80 per cent., according to our state of health, local or general, by the nasopharyngeal defenses and the ciliated epithelium of the respiratory tract down to the terminal lobules. So perfect is this nasopharyngeal barrier that moderately contaminated air is found completely sterilized after passing through it. This explains the negative results obtained by practically all investigators who have attempted to provoke the disease by injecting B. influenza~ into the nasal cavities. The germs were destroyed by phagocytes (the cytoplasm of which can be found to contain them) and the mucus of the respiratory passages long before they could reach the alveoli, which alone in the whole tract afforded the conditions necessary for their growth...



Prophylaxis-—The foregoing remarks have pointedly indicated where protection against infection is paramount, i. e., in the respiratory tract. This is so well established that antiseptic sprays, gargles, fumes and douches are employed by most clinicians.
pink air!

But is it as antiseptics that these procedures act? The recent war has taught us that antiseptics, including the newer ones, in solutions sufficiently strong to kill bacteria, also kill tissue cells. In the nasopharyngeal passages, therefore, if antiseptic solutions are too weak they are useless; if strong enough to destroy bacteria they do harm by inhibiting the local protective functions. Other data showed, however, particularly Lambert's experiments, that while iodine was very active as a sterilizer in a 1 to 2000 solution, it promoted cellular activity. Pharmacology also teaches that iodine is the specific excitant of lymphoid tissues and therefore of phagocytosis.


amazing color, I'd never seen
 this color before...
It was also observed during the war that in toxic gas manufacturing plants, in which emanations of irritating gases, chlorine, sulphur dioxide, etc. (not phosgene), in hardly perceptible proportions permeated the air, immunity was conferred upon workers therein while influenza reigned unchecked in the neighborhood. Shuffelbotham (Brit. Med. ]our., Apr. 19, 1919), who investigated this report in twenty different and widely separated districts in England, found that workmen actually enjoyed a “very high degree of immunity from infection." A. Gregor (Brit. Med. ]our., Oct. 25, 1919) ascertained bacteriologically that workers so exposed showed a marked decrease in the pharyngeal flora even twenty-four hours after exposure to the fumes. Tweddell (letter to Med. Rec., Jan. 24, 1920) has observed similar protection at the Edgemont Arsenal in this country. Consular reports (Amer. Med., Apr., 1905) from Germany had also called attention to the protective influence of evaporating turpentine in the presence of the workmen during an epidemic.


All the practical phases of the question, clinical, experimental and industrial, unite, therefore, in pointing to the value of measures which: enhance the defensive efficiency 0f the respiratory tract as the foundation of our prophylactic procedure. Normally, as previously stated, it's tissues defend us to the extent perhaps of 80 per cent. It is the remaining 20 percent of defensive efficiency that we should aim to promote to obtain complete protection. How may we secure it?


iodine crystals depositing around edges after
candle snuffed

Iodine is superior to any of the antiseptics used because, while provoking a local defensive reaction, it favors the vital activity of the lymphoid and epithelial cells. Yet, it must be employed with due care. Indeed, personal tests showed that even as weak a solution of iodine as l to 2000 caused too much smarting when sprayed into the nasal cavities to be employed, but that when iodine crystals were slowly converted into fumes by the heat of a small alcohol lamp 15 centimeters below them, and mixed with air in the proportion of 0.33 Gm. of crystals to 16 cubic meters of air (the size of a very small room used as inhalatorium) the iodized air could be inhaled comfortably. Any stronger dilution caused a symptom which indicates that the proportion of iodine is too, great, viz., persistent smarting of the conjunctiva after the first slight pricking sensation experienced on entering the iodized air chamber. This affords a delicate test for the adjustment of the mixture to proper proportions by the admission of additional air into the room.


as the surface cools, the crystals grow
The duration of the slight pungency experienced in the upper respiratory tract and dryness, followed by a freer flow of mucus, obtained with 5 grains of crystals, was about one hour. It was found. however, that these effects could be perpetuated indefinitely by dropping tincture of iodine upon the small receptacle over the alcohol flame which had held the crystals. The fumes thus formed sufficed in the area specified, 16 cubic meters, and were inhaled hour after hour without difficulty or causing irritation.


The effects of a stay of but 3 hours in the inhalatorium so charged were unexpectedly noticeable. Although no deep breaths had been taken, the odor of iodine per se (diflerent somewhat from that of the tincture itself) was perceptible the whole of the following day, off and on, that is to say, about 36 hours. This accounts for the fact that Gregor (10e. cit.) had found that the naso-pharyngeal organisms of the workmen exposed to chlorine and other fumes were markedly decreased as much as 24 hours after leaving their plants.

When we consider the superiority of iodine fumes over those to which they were exposed, and also the relative vulnerability of the B. influenza,, there is every reason to believe that 3 hours of exposure to iodine fumes under the conditions mentioned would afford at least protection for an additional 5 hours, during an epidemic, by enhancing defensive efficiency of the whole respiratory tract.

The practical bearing of these observations is that all public places, schools, places of amusement, shops, hotels, churches, offices, factories, barracks, hospitals, etc., where many people spend much time either as pupils, employees, visitors, etc., and which are now foci of infection, could be converted into as many sterilizing and immunizing inhalatoria provided the air in them be kept iodized in the proportion above mentioned by multiplying as needed and distributing evenly throughout the area to be iodized, what apparatus-very simple and inexpensive as we shall see-may be needed for that area. Or, better, where a suitably situated adjourning room is available, fresh air from an open window may be strongly iodized, and driven by a turbine or rotary fans through an enclosed shaft to the occupied room, and in such proportions as to insure the dilution specified. The iodized air can thus be kept pure, escape vents being supplied through lowered upper sashes or transoms for the occupied quarters.

During the hours all such places would be used, all those exposed to the iodized air for 3 hours would be protected at least 5 hours besides, as we have seen, i.e., 8 hours, at least until bed-time, while in a place of amusement, church, etc., and other sterilizing inhalatoria, the protection would extend to the following morning. Yet, absolute safety imposes the need of an iodized air apparatus in every home, thus perpetuating its effects throughout the 24 hours.

To provide for out-of-doors workers, laborers, masons, bricklayers, drivers, street renders, etc., sterilising tents might be provided, but here again the need of an apparatus at home imposes itself, since workers would hardly consent to spend the time necessary during the day, even to protect themselves. Indeed, adequate protection demands that all residences, great and small, should, if legally possible, be made by the municipal authorities and under their watchful care, to be kept iodized, and if possible, at the expense of the commonwealth, to insure execution. This alone would cause complete protection.

Apparatus.—Expensive apparatus is unnecessary. Among the poor whose living quarters are small, what lighting, heating or cooking facilities they possess may be utilized with the aid of slight ingenuity. Or a small open fume box—a 100 cigar box, for instance—may be used, by removing one of its ends and replacing the latter by a piece of wire netting. This netting is used, the box standing on its other end, to support a small metallic cover or saucer, in which are placed the iodine crystals. These, in turn—or the drops of tincture of iodine—are gradually evaporated by the flame of a small alcohol lamp placed on the floor of the upright box, the three walls of which prevent side draughts from disturbing the flame, while forming a chamber of warmed air which propels the iodine upward and disseminates them. The same box can be used for the evaporation of the tincture of iodine drops by nailing to it an elbow support for a glass funnel the beak of which contains a stopper provided with a small hole, so regulated as to allow the tincture of iodine it holds to drop on the evaporating plate as needed.

Where such comprehensive measures cannot be carried out, a small inhaler calculated to permit the inhalation of cold iodine emanations, which are far less dense than the fumes evolved by heat, can be used. It consists merely of a glass tube one end of which is enlarged into a bulb calculated to fit into either nostril. Each end is packed, though not tightly, with a wad of cotton wool. 3 grains of iodine crystals being placed between the two wads, i.e., in the middle of the inhaler. One end of the latter being enlarged and bulb-shaped, the bulb is introduced into each nostril in turn. On inhaling slowly but steadily through it, the iodine emanation will he felt to penetrate far down. To insure filling of the entire bronchial tree down to the alveoli, after removing the inhaler, the nose is closed with the fingers, and efforts to blow the iodine out through the nose, the mouth being shut, are made. The slight warmth and pricking sensation experienced in the nose and throat disappears in a few minutes. Not more than two inhalations from the inhaler should be taken. These suffice, after clearing the nose, to excite a defensive reaction which may be sustained if the procedure is repeated several times a day. Various pocket inhalers available in the shops may be used for the same purpose, but, in an emergency, I found that discarded bacterial vaccine tubes served the purpose very well.

A small inhaler is particularly useful where the air is likely to be contaminated, in tramways. places of amusement, shops, etc. It should be used before leaving home and every 3 hours to keep the nasal mucosa on the defensive. At present, coughing and sneezing individuals are urged to cover their faces, nose, and mouth with their handkerchiefs; but everyone exposed should likewise protect himself with his handkerchief. A small inhaler hidden in it and used materially reduces the danger of infection. A few whiffs suffice. Again, many bacteria inhaled are present at first in the anterior nasal cavities; if the inhaler is used again on reaching home and the nose freely blown additional protection is afforded. Although the January-February, 1920, epidemic afforded ground for the belief that this measure affords protection, thousands of cases can alone determine its value. A priori, it is obvious, however, that the general public measures advocated offer a far greater opportunity for adequate protection than the desultory use of any inhaler.

...

 The small iodine inhaler should be used every 2 hours during waking hours, taking only a couple of whiffs through each nostril and inhaling slowly though deeply. The room, preferably a small one, should, by means of the apparatus described, be filled with iodized air (though not sufficiently so to prove irritating to the eyes), iodine fumes being generated near the patient's bed. The aim should be to check the formation of colonies in the alveoli and to destroy the influenza bacilli in the respiratory tract at the earliest possible moment, the bacilli from the alveolar colonies serving to infect other alveoli. The iodine fumes would also protect the nurse, as they readily penetrate into the mask. The latter should always be worn by her in the patient's room, not only to protect her but also to prevent her becoming a carrier.

If the room is large a bed-tent, the upper part of which would reach above a window, the upper sash of which would be somewhat lowered, would serve to concentrate the iodized air evaporated under it in a small area and increase its efficiency. The patient, however, should be kept warm, though well supplied with fresh air.



Friday, August 10, 2012

merck manual, 1899


A search on "iodine" in the 1899 Merck Manual returns 96 hits. "Iodide", 100 hits. Were I to repeat the search using the term "iodopin" or "iodophorm", even more results would be returned...

Below is a sampling of conditions for which iodine in one or another form was prescribed in 1899. Iodine was certainly NOT the only suggested medicine, I am listing these conditions only to show you the wide range of conditions for which iodine was once prescribed. It was prescribed in many forms, from tincture to potassium iodide to iodized oil, and administered in a variety of ways, from internal dosing to painting to injection to inhalation. Some of the indications are to be expected, such as the use of iodine for goiter or uterine fibroid. Others were unexpected, such as the use of an iodine enema in hepatitis. This manual was published well after the initial iodine enthusiasm in the early part of the century, so I imagine that these treatments were well-established in 1899.


asthma

iodine: painting the line of the pneumogastric nerve with liniment or tincture in pure spasmodic asthma

Hordeolum(stye).- see also, eyelids

Iodine tincture

Meningitis, tubercular

Iodine

Ovarian diseases

Carbolate of Iodine

Smallpox

Iodine

Emphysema

Potassium iodide

Empyela

Iodine

endometriosis

iodine, iodi-tannin, solution of iodine and tannic acid, on cotton wool

Enuresis

Iodine

epydidimitis

iodine

erysypalis

iodine, solution not too strong painted over.

exotosis

iodine, potassium iodide

fever

carbolate of iodine, in the later stages of typhoid, and in chronic malarial poisoning

fractures

iodine, antiseptic dressing

freckles

iodine

glanders and farcy: more info here: Glanders in a Military Research Microbiologist

iodine

glandular enlargements

iodine, internally and painted around, not over the gland.
iodoform, as a dressing to breaking-down glands.
iodoformogen: equitable and persistent in action on open glands.
iodole: internally
lead iodide: ointment

goiter

iodine: internally, and locally as ointment or tincture, and as injection
iodoform
iodoformogen
iodothyrine
potassium iodide

gout

iodide of potassium
iodine
iodoform
iron iodide

gums, diseases of

iodine tincture, locally

hepatitis

iodine, as enema

hepatic diseases

iodine or iodides

hernia

iodine

hydrocele

iodine

hydrocephalus

iodine, potassium iodide

hydrothorax

iodine, injections after tapping.

inflammation

iodine, locally

joint affections- see also arthritis, bursitis, etc

iodine
iodoform
iodoformogen, more diffusible and persistent than iodoform
iodole
iron iodide

keratitis- see also, corneal opacities

potassium iodide

laryngitis, acute

iodine, as inhalation and counter-irritant over neck.

laryngitis, chronic

iodine, as counter-irritant

lupus

iodine, in glycerin

measles

iodine

meningitis, tubercular

iodine

menorhaggia and metrorrhagia- see also, amenorhea, hemmorhage, uterine tumors

iodine

mercurial cachexia - a condition arising from over-use of mercury- containing medications. for more: mercurial cachexia

iodine and iodides
iodopin
iodohemol

nausea

iodine

nevus- see also, tumors, warts

iodine, paint

obesity

iodides
iodoform
iodole

odontalgia

iodine: painted on to remove tartar on teeth; and in exposure of fang due to atrophy of gum.

opthalmia- see also, blepharitis, conjunctivitis, keratitis

iodine, iodoform, iodoformogen, iodole

ozena- see also, catarrh, chronic, nasal

carbolate of iodine
glycerine and iodine
iodine: as inhalation. Much benefit is derived from washing out the nose with a solution of common salt, to which a few drops of the tincture of iodine have been added.
iodopin
iodoform
iodoformogen
iodole

pericarditis- see also, endocarditis

iodides
iodine

peritonitis

iodine

pharyngitis- see also, throat, sore, tonsillitis

iodine, iodoform
iodoformogen

phthisis- see also, cough, hemoptysis, hectic fever, perspiration, night sweats, laryngitis, tubercular, meningitis, peritonitis, etc

iodine: liniment as a counter-irritant to remove the consolidation in early stages, and to remove pain and cough later, as inhalation to lessen cough and expectoration.
iodine tincture
iodopin
iodoform: inhalation
iodole

uterine tumors

iodine



a sampling of iodine preparations found in the 1899 Merck Manual:





Monday, June 11, 2012

Inhalation of Vapors of Iodine




Inhalation of  Vapors of Iodine

source: "Inhalation; it's Therapeutics and Practice",...by Jacob Solis Cohen, 1867

~archaic terms in blue, with definitions at the end of the post


~illustrations picked up at random from the book, just because I like them:) The last one, in particular, has NOTHING to do with iodine!

The close resemblance between tuberculosis and scrofulosis, and the well-known alterative effects of iodine upon diseases of the latter character, especially as they affect the lymphatics and other glands, readily led to the employment of the same remedy in pulmonary consumption; and the volatile nature of iodine suggested its employment by inhalation, for the treatment of affections of the respiratory organs. This vapor has been found of decided efficacy in confirmed phthisis, and in certain forms of catarrh, by Berton, Sir James Murray, Baudelocque, Huette, Chartroulle, Lugol, Chomel, Laennec, Piorry, Dechambre, Corrigan, Scudamore, and many other well-known authorities.


Piorry read a paper on the subject of the treatment of phthisis by iodine inhalations, before the Academie de Medecine (Comptes Rendus, Jan. 24, 1854, see Ranking's Abstract, vol. 20, p. 70) (Archives Generales de Medecine, March, 1854, p. 361), in which he treats of it in very high terms. M. Piorry, after mentioning the circumstances inducing him to employ inhalations of iodine in the treatment of phthisis, says that the results of the experiments, instituted by himself in conjunction with M. Deyne, an interne of his service, were very satisfactory. A striking amelioration took place in many of their patients, which amelioration was permanent, inasmuch as several patients, mentioned in his work on Practical Medicine, were still in the enjoyment of good health.


The successful treatment of hydrocele and tuberculous diseases of the testicle, by injections of solutions of iodine, led to the inference of obtaining similar benefit in pulmonary excavations, but the difficulty, not to mention the temerity, of attempting the injection of tincture of iodine into a pulmonary cavity, or into the air-passages, led to the plan of employing the vapor of iodine. Sometimes the crystals of iodine were employed to evolve the vapor, and sometimes the tincture of iodine was used. In the former instance, two or three scruples of iodine were placed in a wide-mouthed quart jar, from which the vapor would be disengaged spontaneously with greater or less rapidity, according to the temperature and humidity of the atmosphere.


In other cases, one to three ounces of the tincture of iodine were poured into the jar, which was then heated until the vapors of iodine and alcohol were given off. The patients breathed the vapors, taking one deep sighing inspiration at a time, and repeated the effort from one to two hundred times daily, at appropriate intervals, several successive inspirations producing pain in the larynx and bronchi, with cough, although the single inspirations did not produce much irritation.


With Laennec, who surrounded the bed of his consumptive patients with the varec, in order to procure the iodinized vapor, Piorry, too, employed inhalations of iodine during sleep. He placed several saucers containing iodine about the patient's pillow, or attached a number of vials of iodine to the bedposts, so as to saturate the air with iodine, which is given off in sufficient quantity to blue any starched curtains that may be about the bed.


Piorry calls attention to the circumstance, that if a moist starched paper is interposed between the vessel from which the vapor is being liberated, and the patient's mouth, as he takes an inspiration, it turns blue, while the same air breathed upon the paper, after having traversed the lungs, causes no change; from which fact he infers, that the iodine which enters the lungs is absorbed there. The treatment of Piorry's cases was not confined to the iodine inhalations. Most of them took from twenty to sixty grains of the iodide of potassium by the stomach daily. In cases of supposed adhesions, frictions were resorted to with tincture of iodine, one part to nineteen parts of water. Other remedies, as astringents, opiates, and other narcotics, quinine, &c., were given to fulfil various indications; while a nutritious and reparative diet was employed, to which regimen Piorry gives a preference over all the remedies employed, except the iodine.


Thirty-one patients were thus treated during a period of two years, all presenting in different degrees unmistakable signs of phthisis, with the characteristic sputa, and positive plessimetric and stethoscopic evidences of the disease.


In order to determine with precision the effects of the iodine, some charts were prepared, upon which were marked exact delineations of the parts diseased, and representations of the variations in sound upon percussion, which occurred from day to day. After periods varying from four, six, or twenty days, to from six weeks to four months of the iodine treatment, there was in almost every case a diminution of the extent of the surface over which there was at first feebleness of respiration, dulness, resistance, &c., while at the same time, auscultation indicated an amelioration in the condition of the condensed portions of the lung. Numerous patients with cavities in the lungs were apparently cured.


The ultimate results were : decided amelioration in the symptoms and anatomical characters in twenty cases ; disappearance of the anatomical characters and of most of the symptoms in seven cases; death with or without amelioration in four cases.


M. Piorry's conclusions are as follows:


1st. The inhalation of the vapor and tincture of iodine is useful in the cure of phthisis.


2d. In many cases, such inhalation is followed by a diminution in the extent of the indurated parts surrounding tuberculous deposits, and an amelioration in the general symptoms.


3d. It is probable that tubercle itself disappears under the influence of iodine inhalations.


4th. That inhalations of the tincture of iodine may promote the cure of tuberculous cavities.


5th. That after the softening of tubercles, the resulting cavities may cicatrize spontaneously.


6th. That compression of the thorax over the points of disease indicated by percussion and auscultation, may contribute to the cure of the local lesion, and to the prevention of pyaemia.


7th. That iodide of potassium administered internally, and frictions with diluted tincture of iodine over adherent portions of the lung, are also of great utility.


Sir Chas. Scudamore found the irritating qualities of the gas subdued by the addition of a little tincture of conium at the time of employing the inhalation, a higher heat being necessary to liberate the vapors from the conium than is necessary with iodine alone.


Sir Chas. Scudamore (London Med. Gazette, February, 1840), after ten years' experience with iodine inhalations, had acquired increased confidence in their efficacy. His formula at this time was 6 grs. each of iodine and iodide of potassium, with 2 drachms of alcohol, to 5 ounces of distilled water, adding a little tincture of conium at the time of mixing the solution of iodine with the water for inhalation. He began with a drachm or so of the iodine mixture, two or three times a day, increasing the dose, if necessary.


The vapor of iodine may be inhaled from a solution of the tincture in water, by means of a Wolfe's bottle, or other inhaler, no artificial heat being necessary.


Dr. Berton's method consisted in placing into a flask with two openings, some dilute sulphuric acid, to which is added a quarter or half a grain of the hydriodate of potash ; the iodine vapors are promptly disengaged, and are inhaled by the patient from one of the tubes from the flask, the process of inhalation occupying four or five minutes, and being repeated as often as desirable, even to the number of ten times a day.


Dr. Pereira's experience in phthisis, as well as other chronic pulmonary complaints, has not been favorable.


M. Simon relates (Brit.$ - For. Med.-Chir. Rev., July 1861, from L' Union Medicale, March 16, 1861) the results of a number of cases of phthisis pulmonalis treated by M. Chartroulle with inhalations of iodine, a practice very frequent in Belgium. Under his directions, twenty-eight patients in the hospital were treated by the inhalation of the vapor of pure iodine, and of this number only eleven could be said to have derived no benefit from the treatment. In these unsuccessful cases the pulmonary lesions were not modified, but still, the symptoms were not aggravated in any case. In opposition to the statement that iodine vapor produces haemoptysis, it was found that pulmonary hemorrhage ceased more rapidly under this kind of treatment than under other plans which are more generally employed.


 Seventeen patients derived positive benefit from the iodine treatment, and this improvement was observed not only in relation to the general symptoms, but also to the pulmonary lesion itself, as was proved by percussion and auscultation. Out of the seventeen patients but four might be considered as actually cured. One of these cases of cure is the following: A youth 16 years of age, entered the hospital in such an alarming condition that at first the physicians hesitated to submit him to the iodine inhalations. He was in a state of great emaciation, and his skin was almost constantly covered with profuse perspiration ; he had diarrhea, which had lasted for two months, and he had repeatedly suffered from haemoptysis. There were very extensive indurations in the lungs, and at the apex of the right lung there was a cavity of some size, as was shown by very obvious gargouillement. The expectoration also was characteristic. After resting a few days, this young man was subjected to the iodine inhalations, and all the symptoms which had appeared so serious were soon modified in a most remarkable manner. The general symptoms disappeared first, and the body recovered its plumpness with great rapidity. The perspiration, diarrhoea, fever, cough, and expectoration, were soon relieved or removed, and six weeks after admission into the hospital the patient went out quite well.


Several other cases of the same nature are recorded from both the public and private, practice of M. Chartroulle, and in all of them the beneficial results of iodine inhalations are remarkably exhibited. Dr. Simon, who relates the cases, attributes a great part of the efficacy of the treatment to the apparatus employed for inhalation, which, however, is not described in the paper. By this apparatus, it appears, a degree of precision is given to the treatment which consequently becomes the more efficacious, for a dose of the vapor may be estimated with exactness, and the remedy may be made proportionate to the severity of the disease and the strength of the patient.


Lewin (op. cit., p. 202) had employed vapor of iodine in phthisis several times without any favorable results, but all his cases were in the advanced stage.


The inhalation of iodine vapor has been employed in coryza(the common cold). An army surgeon, M. Luc, seized with very bad coryza, attended by fever, severe cephalalgia, and excessive secretion, determined upon trying the effect of the inhalation of iodine vapor. The coryza first appeared at 9 A. M., and the inhalations were commenced at 3 p. M., being repeated every three minutes during an hour, each lasting about a minute. The headache was first relieved, the sneezing then occurring less frequently, the amount of secretion diminishing, and by 6 P. M., all traces of the coryza had disappeared, except a little burning sensation in the throat. Several of the officers have since tried the means with the same results. The inhalation is effected by placing a bottle of tincture under the nose, the hand supplying warmth enough to vaporize the iodine. (Rev. Med., August 31; Med. Times and Gazette, November 11,1865; The Med. Record, March 1, 1866.)


Dr. A. P. Merrill, of New York, formerly Professor of Materia Medica in the Memphis Medical College, and editor of the Memphis Medical Recorder, has for a number of years made extensive use of the inhalation of the vapors of iodine in mucous inflammations of the trachea and bronchi, led to the treatment by the happy results previously obtained in his own case and that of others, by its local application in a convenient form, in cases of chronic pharyngitis and laryngitis. These cases are reported in the Memphis Medical Record, vol. i, 18523, pp. 8, 21, 113; vol. iii, 1854-5, pp. 133, 187, 228, 285 ; vol. iv, 1856, pp. 252, 377.


Dr. Merrill employs the vapor disengaged directly from the crystals of iodine, which are sufficiently volatile in a current of cold air to afford all the strength of vapor that can be conveniently borne by the patient. I make a few extracts from some communications on this subject, kindly furnished me by that gentleman. " In a case of such inflammation beyond the reach of the brush, I found a patient inhaling the vapor of gum camphor through a common quill, but without much effect. I added a few grains of iodine to the camphor, and then the relief obtained was more decided; but in applying this combination to other cases, I met with a difficulty in the liquefaction of the mixture, and then determined to use each remedy separately, by placing it within a small cane tube, with a little coarse wool in each end to prevent the escape of the medicine. I have used tubes of glass, also, but found them to hold the remedies less securely. The cane tubes have answered an excellent purpose, whether employed through the medium of the mouth or the nasal passages, but more recently I have substituted tubes made of hard rubber, so rounded at the ends as to prevent irritation, and the vapor escapes through several perforations at the extremity. With these tubes, which unscrew at the middle for the introduction of the iodine, the teeth, tongue, &c, are protected from any disagreeable effects of the vapor, and the current may be made to impinge in any desired direction.


" Great benefit is derived from iodine inhalations in the more acute affections of the nasal membranes, such as coryza, hemorrhage, and catarrh. They relieve the habitual catarrh of old people, and are advantageous to public speakers and singers, whose vocal organs have become debilitated from excessive exercise in their vocations, and which sometimes show a tendency to oedema of the glottis, and terminate in aphonia."


Dr. Merrill details (Am. Jour. Med. Sci., Jan. 1866) an interesting case of symptomatic bronchial irritation, in which the iodine inhalations were very beneficial. These were made with tubes of cane in the manner previously described. He considers that the iodine acts in chronic cases by exciting a watery secretion which disengages the viscid mucus which frequently induces coughing by its titillation, and that it relieves hyperemia and hypertrophy. He has found benefit from inhalations of iodine vapor, in croup, in oedema of the glottis, and aphonia.


In cases of children, and people unwilling or unable to inhale properly, he attaches a gum hand-bellows by a rubber tubing to the tubes, and thus forces the vapor into the nasal or laryngeal passages.


Dr. Merrill has kindly furnished me with the following notes of a case of profuse bronchorrhoea, which was suppressed by inhalations of iodine.


"Mrs. McL., aged 70 years, had suffered for several months with cough, constipation, and oedema of the feet and legs, with incontinence of urine. She complained especially of excessive expectoration, which had reduced her almost to a skeleton, and it was with difficulty she could walk across the room. I did not see the matter expectorated, which was so offensive that she declined saving it, but both she and her daughter estimated the quantity latterly at a pint to a pint and a half every morning, for it was only in the morning that her cough troubled her. Beginning at three to four o'clock, it continued several hours, during which time the expectoration was free and profuse, and she often passed the remainder of the day without coughing at all.


"I gave her an inhaling-tube, charged with iodine, to be used frequently during the day and night, and directed her to take one-tenth of a grain of arsenious acid three times a day, together with half a grain of calomel at night. This course was continued twenty days with progressive improvement, when (June, 1867) she was entirely relieved of the bronchial disease, and the iodine inhalations were suspended."


Archaic Terms:


phthisis~ 1. A disease characterized by the wasting away or atrophy of the body or a part of the body. 2. Tuberculosis of the lungs. No longer in scientific use. (free online dictionary)


grains~  64.79891 mg, 1⁄7000 of a pound (wikipedia)


cicatrize~ To heal or become healed by the formation of scar tissue. (free online dictionary)


pyaemia~ a type of septicaemia that leads to widespread abscesses of a metastatic nature. It is usually caused by the staphylococcus bacteria by pus-forming organisms in the blood. Apart from the distinctive abscesses, pyaemia exhibits the same symptoms as other forms of septicaemia. It was almost universally fatal before the introduction of antibiotics. (wikipedia)


conium~ aka poison hemlock. "An old remedy, rendered classical by Plato’s graphic description of its employment in the death of Socrates. The Ascending paralysis it produces, ending in death by failure of respiration, show the ultimate tendency of many symptoms produced in the provings, for which Conium Maculatum is an excellent remedy, such as difficult gait, trembling, sudden loss of strength while walking, painful stiffness of legs, etc. Such a condition is often found in old age, a time of weakness, languor, local congestions, and sluggishness. This is the special environment that Conium chooses to manifest its action. It corresponds to the debility, hypochondriasis, urinary troubles, weakened memory, sexual debility found here."  source:  abchomeopathy


drachm~ 27.34375 gr (sixteenth of an ounce)


hydriodate of potash~ potassium iodate!


coryza~ (Medicine / Pathology) acute inflammation of the mucous membrane of the nose, with discharge of mucus; a head cold
[from Late Latin: catarrh, from Greek koruza]