Io-Eyes

Dr. H.A. Goden's Practical Observations from Hufeland's Prat. Heilekunde

Tincture of Iodine.

The author, never having had an opportunity of using iodine in that disease in which it has been so efficacious, goitre being extremely rare in that part of the country he inhabits, but being fully convinced of its powerful action upon the glandular system, he prescribed it in highly diseased states of that system with prudence and effect.

The medicine was exhibited in four cases of complete scrofula in subjects from six to twelve years of age; in all of whom there were evident symptoms of disease as early as their second and third years. The face was swollen and oedematous, abdomen enlarged and hard; the mesenteric glands were evidently increased in size, the glands of the neck hard and swollen; and in various parts of the body, but particularly upon the inner side of the legs, there was a moist, impetiginous, scrofulous eruption, which formed an acid fluid of so caustic a nature, that it inflamed and excoriated the parts liable to come in contact with it. In all these cases there was tinea capitis exedens, and in one the impetiginous eruption was situated on the right side of the face, extending from the eyelids to the under part of the chin; but in the three others, it occupied the inner side of either lower extremity, and the parts of generation. The most serious and troublesome symptom to contend with, was a severe scrofulous inflammation of both eyes; this was particularly distressing in the case of the girl of twelve years of age. Both her eyes had been almost entirely closed for three years; the conjunctiva and sclerotica membranes were greatly inflamed and very painful, and the eye-balls were so constantly covered all over with a puriform acrid lymph, that they could scarcely be seen, particularly of a morning, when the lymph was so abundant that the orbits appeared entirely filled with it. The eye-lids were generally sealed together; corrosive tears were continually flowing from the eyes; and the intolerance of light was so great, that the patient could not suffer it without the most distressing complaints. A physician, the author's predecessor, despaired of a cure, and pronounced the inevitable loss of both eyes. In this case, the eye-lids were hard, and swollen to the size of a pigeon's egg, and the eruption occupied the face and other parts of the body. During the long development and continuance of this disease, all the usual anti-scrofulous remedies were perseveringly used for months together, without any other results than partial and temporary amelioration of the disease, which invariably broke out with renewed vigour during the exhibition of the very same medicines, that appeared a little before to have opposed a barrier to its further progress. The muriate of barytes, aethiops, calomel and cicuta, acetated kali with the saponaceous extracts and the tincture of rhubarb, acorn coffee and violet tea for common drink, cinchona and the extract of madder, aromatic baths, and malt baths, were all tried with little or no advantage. Ointments of red precipitate and opium, of the white oxyd of zinc; eye waters of the muriate of mercury, and with opium, belladona and stramonium, were used conjointly with setons and perpetual blisters, but all without improving the state of the eyes. An ungtient of rose ointment and white oxyd of zinc checked for a time the eruption, and diminished its acrimonious discharge.

illustration from Oculus Artificialis
Teledioptricus Sive Telescopium

Under these unfavourable circumstances, all the best and most active remedies havingor only temporarily relieved, the author concluded to try the effect of the tincture of iodine, which, on foreign report, he had learnt, had been so useful in diseases of the glandular system. All medicines, except the white precipitate ointment for the eyes, were laid aside; and five drops of the tincture of iodine in barley or sugar water were given twice a day. The dose was increased one drop every two days until it amounted to ten drops, which quantity was administered regularly without further increase. No unpleasant symptoms arose from the use of the iodine, except that the appetite and digestion became impaired; the bowels were occasionally too much bound or too loose, and there was a flatulent swelling of the abdomen. Whether these symptoms were accidental, or the effects of the iodine, cannot be determined; but they were relieved by an infusion of quassia with cinnamon and the elix. Aurantior, comp. The beneficial action of iodine was most striking and rapid in this case, for by the fourteenth day there was a general and evident improvement in the state of the patient; the inflammation of the eyes had diminished much; the puriform discharge from them was less, milder and thicker; the patient could now look at the light without suffering the previous intolerable pain and plentiful effusion of tears; the rolling of the palpebrx had disappeared; the cutaneous eruption was considerably better, and the general habit of body was greatly improved. In four weeks from the beginning of this course of medicine, the change for the better was very great; at this time the ophthalmia and the puriform discharge were no longer present, the eyes were a little weak, and the lids were slightly disposed to agglutination during sleep; these symptoms yielded to a collyrium of rose water and tincture of opium. The iodine was continued in doses of ten drops twice every third day for four weeks longer, when its use was suspended, there being no longer any traces of scrofula. In order to invigorate the constitution, and destroy all tendency to the disease, an infusion of cinchona, with extracts of cinchona, (prepared without heat,) madder, and acetate of potash, was prescribed, and continued for some months. At first, the infusion was taken every second or third day, in the dose of three tablespoonfuls; but at a later period, it was taken in the same quantity about once a week.  With the same view of strengthening the system, the patient was directed to take twelve baths, prepared with Rad. Calami. Baccae and Herb. Juniper, Herb. Sabinx, and afterwards twelve of malt. By these means, a complete and radical cure was effected, and the patient is now (eighteen months since the suspension of all medicines) a strong, fresh and blooming girl.

In the other three cases, the scrofulous diathesis was equally developed, and had produced the same diseased appearances as in the case already described; and in these also, the usual remedies had been used for years without effect, but they were radically cured by the tincture of iodine, which, on account of the youth of the subjects, was at first given in doses of two drops twice a day, and increased one drop a dose every second day till eight drops were taken twice a day. In none of these cases did the author perceive any bad effects from the iodine; they were all cured in a space of from six to ten weeks.
Establishing his opinion upon the success of iodine in the four cases above, the author concludes that it is the most effectual and certain remedy in confirmed and fully developed scrofula, which we know of, particularly when the eyes are much inflamed, and the glandular system greatly diseased. In cases of more partial and recent scrofula, the usual remedies are alone sufficient, and indeed preferable to the iodine; but when the eyes, the skin, and the glands, are diseased, it is particularly indicated.

illustration from Oculus Artificialis Teledioptricus Sive Telescopium

Johann Zahn's illustrations just thrown in there because they're really cool.

text source: The Medical Recorder: Of Original Papers and Intelligence in Medicine and Surgery, 1826

link

MAMMARY AND PAROTID GLANDS IN GYNECOLOGY

article source: The Therapeutic Gazette, 1899


MAMMARY AND PAROTID GLANDS IN GYNECOLOGY

parotid gland, image source, wiki

Any consideration of the subject of organotherapy in gynecology would not be complete without reference to the results obtained from the administration of the desiccated powders of the parotid and mammary glands, or of the extracts of these glands, with which I have had no experience. These drugs have been employed by others with much satisfaction in the disorders and cachexias that seem to be consequent upon the presence of fibroid tumor of the uterus and certain chronic ovarian diseases. The credit of having brought the subject to the attention of the profession must be attributed to Dr. Robert Bell, of Glasgow, and Dr. John B. Shober, of Philadelphia.

As early as 1896, 1 Bell stated that it would appear that the parotid gland exerts a most powerful influence upon the ovaries, and that when disease exists in these organs it can be brought under subjection by the administration of the parotid glands of healthy young sheep, calves, and pigs. He further stated that it was beyond dispute that uterine fibromata, as well as hyperplasia and flaccidity of the uterus, can be most beneficially affected by the employment of the mammary glands of healthy animals. This, he said, is also true of certain diseases of the ovaries.

This form of treatment of ovarian, tubal, and uterine disease was suggested to him by the physiologic relationship which exists between these organs, as shown by mammary enlargement in pregnancy and metastasis from the parotid gland to the ovary in mumps. The effect of parotid gland upon a diseased ovary is so pronounced, especially if the uterine affection be simultaneously treated by ichthyol or other appropriate remedy, that it would be wrong, in his opinion, not to employ this remedy before resorting to operation.

In the Scottish Medical and Surgical Journal for July, 1897, Bell states that during the past two years he has obtained most favorable results in over sixty cases of enlarged and painful
ovaries which would certainly at one time have warranted oophorectomy. At the time of writing these women were not only perfectly well and free from pain, but also remained in possession of their ovaries. He also reported interesting cases of uterine fibromata, and uterine hemorrhages, that were either cured or remarkably benefited by the use of the elixirs of the parotid and mammary glands administered in drachm doses three times daily, or by the use of three five-grain palatinoids of the desiccated glands.

Bell reports that in cases of uterine hyperplasia there can be but little doubt that mammary gland administered in from five- to ten-grain doses three times a day has acted in a marvelously short time in promoting a speedy return to the normal condition.

  Menorrhagia and metrorrhagia, frequently accompanied by dysmenorrhea, have completely disappeared in the course of a few weeks, and when local treatment has simultaneously been adopted the recovery has been proportionately rapid.

John B. Shober,2 reports four cases of fibroid tumor of the uterus treated with mammary gland, and four cases of ovarian disease treated with parotid gland, with excellent results. He found that in the uterine cases — the women all being under the age of thirty - five years, and therefore far removed from the menopausal influence—and without the aid of any other form of treatment, there was a steady and progressive decrease in the size of the tumor, together with a steady improvement of the general health. Under the influence of the drug menorrhagia and metrorrhagia ceased, and the menstrual periods recurred at regular intervals. He believes that the mammary gland exerts a powerful influence upon the uterine muscle or connective tissue, acting in a manner somewhat similar to ergot, and quite distinct from thyroid extract, which influences especially the epithelial elements of the endometrium.

The mammary gland has never, in Shober's experience, given rise to any of the unpleasant and dangerous constitutional disturbances that often follow the prolonged use of thyroid extract; it acts rather as a tonic than as a depressant to the system. The effect of the drug in checking menorrhagia and metrorrhagia induced him to use it in hemorrhages  not
 dependent upon the presence of fibroids, and in one case of subinvolution after labor. The results were very gratifying. He employs the desiccated powder of the sheep's mammary gland, each grain of which is equivalent to ten grains of the fresh gland. Two grains (twenty grains of the fresh gland) is made into a tablet together with three grains of excipient, and from three to four tablets are exhibited daily. In larger doses cramp-like uterine contractions are produced. Positive results may be expected in from six to eight weeks.
Shober has used parotid gland only in cases of ovaritis, in enlarged, congested, and exquisitely tender ovaries, and in cases of ovarian neuralgia and ovarian dysmenorrhea. The desiccated powder is used in the same dose and form as the mammary gland. The results he obtained by this course of treatment in selected cases were most gratifying.

1 International Medical Journal, July, 1896, pp. 379-386; British Gynecological Journal, 1896-97, xii, pp. 157-170; Lancet, 1896, vol. i, p. 1496.

2 American Journal of Obstetrics, Volume 38, No. 3, 1898; Medical News, August 27,  1898; American Journal of Obstetrics, Volume 39, No. 2, 1899

Organotherapy in Gynecology: thyroid extract and uterine fibroids, endometriosis, etc.

article source: The Therapeutic Gazette, 1899

By W. A. Newman Dorland. A.M., M.D., Instructor in Gynecology in the Philadelphia Polyclinic; Assistant Obstetrician to the Hospital of the University of Pennsylvania.


THYROID THERAPY IN GYNECOLOGY

endocrine system, image, wiki

Of all the forms of organotherapy it will without doubt be safe to assert the marked preeminence of the extract of the thyroid gland. None of the glandular extracts have been more frequently used, and certainly none in a greater variety of pathologic conditions.
Whatever the physiologic action of the thyroid gland may be, it has long been recognized that its secretion—as also the ovarian —exerts a profound influence upon the body metabolism, though of a directly opposite and conflicting nature. Its presence in a normal degree is essential to the maintenance of the physical equilibrium. Thus, through the investigations of the pathologists, we now know that in cretinism and its allied condition, myxedema, either this gland or its functional activity is absent; and in those cases of exophthalmic goitre in which extirpation of the gland was practiced a most alarming train of symptoms shortly developed, directly traceable to the removal from the system of the glandular influence. An excess in the normal secretion of the gland will likewise be followed by an annoying series of phenomena such as will be noted in hypertrophy of the gland or in Basedow's disease.

At once two propositions suggest themselves, namely, in cases of the first class — that is, where there is absent or deficient thyroid action—the administration of thyroid extract to supply the deficiency should be followed by an amelioration of the clinical phenomena; and in cases of the second class — that is, where there is excessive thyroid secretion — extirpation of a portion of the gland or the administration of some antagonistic extract should result favorably. These propositions were shortly tested clinically and found to be sound in theory. The administration of the various forms of thyroid extract in cases of altered or absent thyroid function is always followed by a marked improvement of the condition present, while partial thyroidectomy has frequently resulted most advantageously in the treatment of exophthalmic goitre.

To clinical experimentation based on the foregoing theory must be attributed a series of interesting and unexpected results in thyroid therapy, such as the value of its employment in gynecologic and obstetric conditions, and its undoubted usefulness in the reduction of obesity. The rationale of its employment in the latter condition has been suggested by Robert Hutchinson, 1 who explains its action by an increased combustion of the nitrogen-bearing substances in the body, especially of the fat, but of the muscles also to a lesser degree.


Jouin f, 2 was the first of the modern writers to call attention to the close relationship existing between the thyroid gland and the pelvic organs, although Catulle states that this relationship was well known to the ancients. In addition to the influence exerted by the uterus — especially at the time of the menopause, when the ovarian influence is dying out—upon the size of goitres, he was the first to observe a diminution in the size of a fibroid tumor under the administration of thyroid extract given to reduce obesity. He obtained a considerable amelioration, and at times even a cure, of uterine fibromata and their symptoms, and of metrorrhagia rebellious to all other conservative means. In cases of purely functional hemorrhage the results had been a complete and lasting cure; also in those of hemorrhage at the menopause or dependent on flexions, versions, and other displacements. In his hands the growth of fibrous tumors was always checked by it,
and it often led to their retrogression. When it was employed early it cured them. In consideration of his results obtained in cases of this kind, as well as in the case of keloid and prostatic enlargement, he suggests that this method of therapy may be of value if applied to tumors of less advanced development, as, for example, sarcomata.



Hertoghe, 3 has found that women deprived of the thyroid gland are subject to excessive menstrual discharges; as they grow older the menses last longer, and finally become almost a constant flow. He has also noticed that a hypertrophied thyroid is always accompanied by an early and copious mammary secretion. He has demonstrated by tests on milch cows and other animals that the secretion of milk is much increased by the ingestion of thyroid extract. From his experience he concludes that myxedematous hemorrhage is directly amenable to thyroid treatment, and also hemorrhages due to even an old endometritis or ovaritis. Cancerous hemorrhages cease after three or four days of thyroidization. The pain, swelling, and congestion also decrease to a noticeable extent. Thyroid treatment, he claims, is especially indicated in cases of frequent abortion, in which the menstrual flow is so excessive that it sweeps away the impregnated ovum. He cites an instance of a woman who was able to conceive and bear a child through the action of thyroidin after many years of sterility. Thyroidin, he finds, is also useful in cases of uterine myoma, prolapsus, or retroflexion with hemorrhage, and, in general, in all cases in which it is necessary to reduce the size, sensibility, or congestion of the uterus. On account of the peculiar action of thyroidin in stimulating the lactal secretion, it should be administered if this secretion seems to be diminishing. It has also been found that in some phases of insanity, particularly those of the puerperal, adolescent, and climacteric periods, thyroid extract seems to have marked beneficial effects.

H. B. Stehman, 4 of Chicago, administered  thyroid tablets thrice daily to six patients exhibiting various forms of menstrual and other disturbances, including menorrhagia, metrorrhagia, amenorrhea, ovarialgia, and extreme nervousness. Each tablet represented about one-sixth of a sheep's thyroid. In each instance a most notable improvement was


  observed within the space of several weeks. It seems conclusive, therefore, that in these cases of pelvic congestion and sexual neurasthenia thyroid extract exerts a most remarkable and beneficial effect.



M. R. Latis, 5 believes that the thyroid juice exerts an inhibitory or vasoconstrictor power upon the pelvic genital organs, which is proved by the gradual diminution and final cessation of the menstrual flow under the prolonged use of the remedy. Menorrhagia and hemorrhages due to endometritis, ovaritis, and even cancer are greatly benefited by it.
Robert Bell, 6  quotes the experience of various surgeons and neurologists with reference to the thyroid gland and the genital organs. He states that Charcot, having seen women affected with exophthalmic goitre cured after pregnancy, did not fail to advise marriage, on therapeutic grounds, in the treatment of this disease. Bouilly, Tuffier, Guinard, Picque, and Bloch, having had occasion to operate on patients affected with fibroma of the uterus or salpingo-oophoritis, in whom coexisted goitres, some of which had previously resisted all treatment, have seen the thyroid tumors disappear, or at least be considerably diminished in size, after the extirpation of the pelvic organs. Bell especially emphasizes the pathologic relationship of the thyroid body to the womb and believes that the vitality of the latter may depend to a large extent on the integrity of the thyroid function. This fact especially seems to be exemplified by the marked prevalence of metrorrhagia in myxedematous conditions. He believes also that the thyroid gland especially influences the health of the skin and mucous membranes and subjacent connective tissue.

In three cases of uterine fibroids Kleinwachter, 7  found that thyroid extract exerted a favorable action in controlling the hemorrhage. In these cases the intermenstrual period was also prolonged or menstruation ceased entirely for a number of weeks. It was impossible to determine any diminution in the size of the tumors.

W. M. Polk, 8 states that during the past two years he has employed thyroid extract in fifteen cases of fibroid tumor of the uterus. In all but one he obtained good results. In four of the cases there occurred a distinct diminution in the size of the growth. He recommends the early and long administration of the extract in daily doses of 2% grains. 



J. Inglis Parsons, 9 employed thyroid extract in five cases of fibromyoma of the uterus. Four of these were women of about the age of forty years, with old hard fibromata of many years' standing. No appreciable diminution in size followed after a three months' course. In the fifth case, a young woman twenty-five years of age, with a large, hard, nodular fibromyoma almost filling the pelvis and dipping down into Douglas's pouch, there occurred a distinct reduction in size. The symptoms of morning sickness and attacks of retention of urine entirely disappeared in three months' time.



Having observed in conjunction with the good results following the employment of thyroid extract in the treatment of sporadic cretinism, myxedema, and some cases of mental feebleness, more or less marked increase in the activity of the metabolic processes of the body, Stawell, 10 was led to believe that the same agent might be reasonably expected to increase the metabolism of the mammary gland in suitable cases. Accordingly he employed thyroid tablets (presumably each representing one grain of dried gland), given from three to five times a day, in nine cases of nursing women, and in seven of these distinct increase in the quantity and apparent improvement in the quality of milk secreted followed.

R. v. Braun. J, 11 also reasoning from the same basis of profound alteration in the bodymetabolism as a result of thyroid medication, has suggested the use of the drug in obstetrics in cases of contracted pelvis in order to prevent heavy development of the fetus. He cites an instance of a woman with a funnel-shaped pelvis, protruding ischiatic spines, and an exostosis at the right iliopubic eminence, who had been delivered by craniotomy several months previously. In her succeeding pregnancy from the beginning of the fifth month she was put on one tablet of thyroidin daily. During the first part of the remaining period of pregnancy she increased slightly in weight, and during the latter part she decreased. The fetus seemed to remain small and was allowed to go to term. She was then delivered of a 3200-gramme living child. The previous child weighed 4000 grammes


 at birth. The difference in weight of the two children may or may not have been due to the thyroid in.



Cheron, 12 holds that thyroid extract is an excellent remedy in threatened abortion with hemorrhage, and is valuable in preventing the arrest of uterine involution after childbirth, and that it is potent against the premature return of the monthly periods. Moreover, it is a valuable galactagogue. In other, words, it stimulates the mammary secretion while it lessens functional activity of the uterus. In his hands it has also proved valuable in the control of all forms of uterine hemorrhage, whether this be due to endometritis, tumor, or lesions of the adnexa.

The contraindications to the employment of the drug are: tuberculosis, since this seems to be stimulated rather than arrested, and grave heart disease, where it should be administered with the utmost care, and should be discontinued at once upon the first suggestion of tachycardia. The symptoms of thyroid intoxication are tachycardia, oppression, exophthalmus, glycosuria, albuminuria, and irritability. In certain cases the drug produces rapid emaciation, and sometimes gastric vertigo will be observed.
Four cases of uterine fibromata and two cases of hemorrhagic endometritis have been treated by me during the past winter by means of thyroid extract, with the following results:

Case I.—A. E., colored, thirty-eight years of age, gave birth to her last child twenty-two years ago. She complained of great loss of flesh during the preceding six months, associated with severe radiating pain in the lower abdomen. Examination revealed a number of fibroid nodules on the anterior uterine wall. Five-grain tablets of thyroid extract were administered thrice daily, and in one week's time she reported a marked diminution in her pelvic pain.

Case II.—S. K., colored, aged forty-seven years, single, complained of pain in the back and right ovarian region, and a persistent though slight leucorrhea. Her menses had never been regular, and were now profuse. Under the thyroid extract in two weeks she pronounced herself much better. The duration and quantity of the menstrual flow were greatly diminished.

Case III. — M. M., colored, aged forty-eight years, had given birth to her last child thirty


 years before. She was suffering from the menopausal hot flashes, a constant leucorrhea, and pain in the back and left ovarian region. She had a small fibroid in the posterior uterine wall. On December 3, 1898, the thyroid medication was begun, and on the 16th she stated that she was improved and the pain in her back was gone. Four days later her menses began and lasted for four days, the shortest time for years. They had formerly been profuse and persisted for from seven to ten days. The leucorrhea was also much less in amount.



Case IV.—L. R., colored, aged thirty-five years, single, complained of pain in the left ovarian region, frequency of micturition, and a mucopurulent leucorrhea. Her menses occurred at three-week intervals and lasted profusely for five days. Examination showed the presence of uterine fibroids with a small mass firmly fixed in the pelvis and fibroid in nature. On September 13, 1898, the thyroid tablets were administered. One week later her pain was less and she thought she was a little better, though there was no change in the micturition. At that time the tumors seemed to be undergoing some alteration in shape, and the mass in the pelvis had become freely movable. Six days later she stated that she knew she was better than when she first came for treatment; she had less pain in the back and side. On October 6 she was feeling better generally; her menses had returned on September 27 and lasted three days. They were profuse, but no more than usual. On November 1 the tumor was decidedly smaller and freely movable. Her bleeding was not so pronounced. At her last visit, on December 6, all of her symptoms were relieved.

Case V.—K. G., white, aged twenty-seven, married three years, and sterile, came for the relief of sterility. Her menses had been profuse from puberty, lasting for five or six days, and always clotted. In August, 1898, rapid dilatation and curettage were performed in the hope of relieving the sterility. On March 3, 1899, she returned and stated that she had been flooding for seven weeks, and was suffering from severe left ovarian pain. Examination showed a slightly enlarged endometritic uterus. The thyroid extract was administered, and in forty-eight hours the bleeding ceased and has not returned at the time of writing. The pain also had disappeared and the patient was feeling well.


Case VI. — E. E., a single girl, nineteen years of age, had been flooding for three weeks. The uterus was normal in size, though very sensitive. Thyroid extract in doses of grains three times daily controlled the bleeding in three days time, and also materially lessened the amount of pain.

The following deductions would seem justifiable in the light of the foregoing reports:

1. The thyroid gland, in addition to its general effect upon the metabolism of the body, exerts an inhibitory action upon the pelvic genital organs, and upon the uterus in particular. This action seems to be especially marked upon the epithelial elements of the endometrium.

2. As a result of this inhibitory or vasoconstrictor action there follows a retardation of hemorrhages from the uterine mucosa.

3. This action is directly antagonistic to that exerted upon the uterus by the ovarian secretion.

4. In cases in which this conservative influence is deficient or absent, it may be restored by the ingestion of fresh thyroid gland or desiccations or extracts of that organ.

5. In gynecology, thyroid therapy is especially indicated in hemorrhagic affections of the uterus and in all forms of pelvic congestion, notably in uterine fibromata, hemorrhagic endometritis, menopausal hemorrhages, and chronic tubal disease.

6. The best results are to be expected in fibromata and pathologic conditions of recent development. The more chronic the case the more rebellious will it prove to thyroidization.

7. The thyroid influence is also found to cause an increase in the metabolism of the mammary gland, and the treatment is therefore indicated in all cases of insufficient lactation.

8. The drug may be administered in the form of the fresh gland substance; as a desiccated powder of the fresh gland; in tabloids of the desiccated gland; as the fresh juice; or in one of the various extracts of the gland, administered preferably in the form of tabloids. The same results may be obtained by direct transplantation of the thyroid gland from the sheep to the human subject. Because of the difficulty experienced in procuring the fresh gland and the repugnance which patients exhibit in consuming it, it is well to administer it in the dry form prepared by druggists—in tablets, pastilles, or capsules —in doses of 2% to 5 grains three or four times daily. The average daily dose is 15 grains.

9. Owing to the tendency to thyroid intoxication it is well to discontinue the drug for a period of a week to ten days at regular intervals during the course of the treatment.

1) British Medical Journal, July 16, 1898




 2) Nouv. Arch. d'Obstet. et de Gynic, 1895, No. 6; La Gynic, June, 1806.

3) Rev. Med., Jan. 4, 1899

4) American Gynecological and Obstetrical Journal February, 1897

5) Dublin Journal of Medical Science, Sept. I, 1897 

6)  Scottish Medical and Surgical Journal, July, 1897

7) Zeitch f Geb u Gynak, 1898

8) Medical News, July 3, 1897

9) Lancet, July 23, 1896 

10) Intercolonial Medical Journal of Australasia, April 20, 1897

11) Cent F. Gynak, 1896

12) Rev Medico-Chirurg, des Maladies des Femmes, Nov 25 and Dec 25 , 1896

Dr. H. Anders' Iodine Water

Our newest addition to the Iodine History Virtual Museum! I present a pamphlet, "Dr. H. Anders' Iodine Water"', circa 1860. I love the cover illustration, lil' Miss Iodine :)

Dr. H. Anders Iodine Water pamphlet- cover

Dr. H. Anders Iodine Water

Dr. H. Anders Iodine Water pamphlet- back cover

I found an image of one of the bottles online, at the Museum of Historical Medical Artifacts. I would love to have one of these!

Dr. H. Anders Iodine Water Bottle

from "The Medical World"' 1857 re: iodine water...

 IODINE WATER.

Having made reference, a week or two since, to a new preparation of iodine, under the impression that there could not be an aqueous solution, the following communication is not only braced by the declaration of Dr. Chilton, of New York, that each fluid ounce contains half a grain of the iodine, but Dr. Anders explains away the objections that might be urged against a long-continued use of iodine in any form.

To The Editors:

Gentlemen, — Allow me briefly to reply to your article, of 29th October, in The Medical World, relative to Iodine Water. I am the physician and chemist you allude to as the discoverer of the only process known for dissolving iodine in pure water; and I contend it enables the Faculty to exhibit that important therapeutic agent with the most beneficial effects, and unaccompanied by those objectionable results which too often follow the administration of iodine in the ordinary well-established officinal preparations. I contend that if the use of iodine has ever resulted in the obliteration of the glands, or in grave injury to the scrotum, it must have arisen from its usual combination with potassium, mercury, &c. ; for in my personal experience of the past two years, I have exhibited the iodine dissolved in water only, in hundreds of cases of consumption, scrofula, palsy, rheumatism, &c, and always with the happiest results. In one case of pulmonary affection, I gave it to a lady constantly for six months, without occasioning the slightest appearance of the absorption of the breast, and the patient is now hearty, strong, stout, and doing well. In another case I administered the iodine water, for six months, to a gentleman, and the result was his restoration to perfect health, with no diminution whatever of his virile energy. I might adduce other and equally striking instances. The names of the parties alluded to are at your disposal, but I forbear for want of space. I present the facta merely to show the " sovereign therapeutic energy of the new medicine," as you felicitously term it, and at the same time to demonstrate that none of the evil consequences flow from its long-continued use, which we are so ready to apprehend when iodine is given in combination with some other article of the pharmacopoeia.
Yours, respectfully,

Henry Anders, M. D. New York, Nov. 7, 1856.

I have analyzed the " Iodine Water," prepared by Dr. Anders, and find it to be a solution of pure iodine in water. It has long been a desideratum to prepare iodine so that it can be administered in its uncombined state; this preparation by Dr. Anders enables us to effect that object. Each fluid ounce of the water contains about half a grain of iodine.
I consider it a valuable preparation, and one which will prove serviceable in all those cases where the use of iodine is indicated.

James R. Chilton, M. D., Chemist. New York, May 22d, 1856.

Iodine as counter-irritant, part 2

More on the use of iodine as a counter-irritant. Follow the link for more information including a lot of case histories, I have copied the intro and a few plates, with instructions. The take-home point is that the counter-irritant must be applied AWAY from the area of local inflammation, over the next "vascular territory".

The Treatment of Surgical Inflammations by a New Method ~ 1870

Other means of counter-irritation are discussed in the book, I focus on IODINE.

An introduction to the concept can be found here:

 http://iodinehistory.blogspot.com/2012/09/iodin-as-counter-irritant-artificial.html


KEY POINT~ What are the principal conditions which are needed for the prosperous beginning and progress of an inflammation? An inflamed part must have increased space —more room for swelling, it must have more blood, it is all the better for perpetual unrest. There must be no other inflammation near to interfere with it—two inflammations do not flourish together.

In the following pages I assume (and the results recorded hereafter justify the assumption) that the- inflammatory process is one and the same process wherever it- may occur, and that the best remedies for any inflammation are the best in all. That drugs have, for certain purposes, great utility I do not deny. Putting aside, however, specific inflammations I know no drug, or combination of drugs, that can cure an inflammation. Counter-irritation can unquestionably cure inflammations. Let me cite one fact among many. An inflamed patellar bursa, before chronic thickening sets in, can be most certainly cured by a ring of blister placed around it, when every other remedy fails. Seeing that counter-irritation could do what no other remedy could, I put a ring of counter-irritation around abscesses, carbuncles, cellulitis, and other inflammations, and discovered striking and rapid results. I next sought to find out the most favourable localities for counter-irritation in every inflammation.

It appeared to me that it should always be established over the next, or another, vessel or vascular territory.

I knew that even and gentle pressure could rapidly arrest some, especially chronic, inflammations. For removing the products of inflammation I knew no remedy to be compared with it. I used it, therefore, in all accessible inflammations.

The best mode of using the best remedies (counter-irritation, pressure, rest, and a few others) in every inflammation is not a routine treatment. Take counter-irritation alone; there is endless scope for individual and independent judgment in the determination of its best localities, best degrees of intensity, best extent and configuration of area, and best modes of production. It is the same with the other remedies advocated in these pages.

One of the greatest advantages of counterirritation is this—it immediately and efficiently relieves inflammatory pain. Most patients are eager to exchange a continuous, dull, wearing, inflammatory pain for a temporary smarting.

The cases are very briefly reported, as they are intended simply to illustrate the effects of treatment.


The following diagrams are mostly drawn from actual cases. The dotted lines show the extent of counterirritation, of a moderate character, as effected by iodine pigment. Unless otherwise indicated, the whole circumference of the limb is irritated.

PLATE I.
Fig. 1.—Extent of counter-irritation in a large abscess of the fore-arm. If the first application of iodine is efficient, the relief of pain is striking and immediate. See Mr. Hodges's case of Mammary Abscess, and Mr. Turton's cases of Carbuncle.

Fig. 2.—Shows singular appearance, after twenty-four hours of counter-irritation, in removing inflammation, and circumscribing pus. I have several times seen this tumourlike collection of pus removed in a few days by continued counter-irritation.

Fig. 3.—Extent of counter-irritation (iodine) in abscess of popliteal space. An iodine paint is applied to the whole circumference of the limb within the dotted lines.

PLATE V.

Fig. 1.—Counter-irritation in carbuncle. A mild form should be more extensive, as in next fig. also.

Fig. 2.—Counter-irritation in a single boil, and in a cluster of boils.

Figs. 1 & 2.—Show extent of moderately vigorous (iodine pigment) counter-irritation in synovitis and early articular ostitis of knee and ankle.

Fig. 3.—Is intended to show use of actual cautery in severe articular ostitis of shoulder. One stripe is at the front, one at the back of the joint, and one midway between the two.

PLATE XIV.

Fig. 1.—Shows mode of using counter-irritation (acetum lyttao in severest, iodine liniment in less severe cases) in purulent inflammations, especially gonorrheal, of conjunctiva. Where counter-irritation must be repeated or kept up, two horseshoe shapes, one within the other, are useful.

Fig. 2.—Shows sharp counter-irritation in the more acute laryngeal inflammations.

Fig. 3.—A milder counter-irritation in the less acute inflammations.

merck manual, 1899

A search on "iodine" in the 1899 Merck Manual returns 96 hits. "Iodide", 100 hits. Were I to repeat the search using the term "iodopin" or "iodophorm", even more results would be returned...

Below is a sampling of conditions for which iodine in one or another form was prescribed in 1899. Iodine was certainly NOT the only suggested medicine, I am listing these conditions only to show you the wide range of conditions for which iodine was once prescribed. It was prescribed in many forms, from tincture to potassium iodide to iodized oil, and administered in a variety of ways, from internal dosing to painting to injection to inhalation. Some of the indications are to be expected, such as the use of iodine for goiter or uterine fibroid. Others were unexpected, such as the use of an iodine enema in hepatitis. This manual was published well after the initial iodine enthusiasm in the early part of the century, so I imagine that these treatments were well-established in 1899.


asthma

iodine: painting the line of the pneumogastric nerve with liniment or tincture in pure spasmodic asthma

Hordeolum(stye).- see also, eyelids

Iodine tincture

Meningitis, tubercular

Iodine

Ovarian diseases

Carbolate of Iodine

Smallpox

Iodine

Emphysema

Potassium iodide

Empyela

Iodine

endometriosis

iodine, iodi-tannin, solution of iodine and tannic acid, on cotton wool

Enuresis

Iodine

epydidimitis

iodine

erysypalis

iodine, solution not too strong painted over.

exotosis

iodine, potassium iodide

fever

carbolate of iodine, in the later stages of typhoid, and in chronic malarial poisoning

fractures

iodine, antiseptic dressing

freckles

iodine

glanders and farcy: more info here: Glanders in a Military Research Microbiologist

iodine

glandular enlargements

iodine, internally and painted around, not over the gland.
iodoform, as a dressing to breaking-down glands.
iodoformogen: equitable and persistent in action on open glands.
iodole: internally
lead iodide: ointment

goiter

iodine: internally, and locally as ointment or tincture, and as injection
iodoform
iodoformogen
iodothyrine
potassium iodide

gout

iodide of potassium
iodine
iodoform
iron iodide

gums, diseases of

iodine tincture, locally

hepatitis

iodine, as enema

hepatic diseases

iodine or iodides

hernia

iodine

hydrocele

iodine

hydrocephalus

iodine, potassium iodide

hydrothorax

iodine, injections after tapping.

inflammation

iodine, locally

joint affections- see also arthritis, bursitis, etc

iodine
iodoform
iodoformogen, more diffusible and persistent than iodoform
iodole
iron iodide

keratitis- see also, corneal opacities

potassium iodide

laryngitis, acute

iodine, as inhalation and counter-irritant over neck.

laryngitis, chronic

iodine, as counter-irritant

lupus

iodine, in glycerin

measles

iodine

meningitis, tubercular

iodine

menorhaggia and metrorrhagia- see also, amenorhea, hemmorhage, uterine tumors

iodine

mercurial cachexia - a condition arising from over-use of mercury- containing medications. for more: mercurial cachexia

iodine and iodides
iodopin
iodohemol

nausea

iodine

nevus- see also, tumors, warts

iodine, paint

obesity

iodides
iodoform
iodole

odontalgia

iodine: painted on to remove tartar on teeth; and in exposure of fang due to atrophy of gum.

opthalmia- see also, blepharitis, conjunctivitis, keratitis

iodine, iodoform, iodoformogen, iodole

ozena- see also, catarrh, chronic, nasal

carbolate of iodine
glycerine and iodine
iodine: as inhalation. Much benefit is derived from washing out the nose with a solution of common salt, to which a few drops of the tincture of iodine have been added.
iodopin
iodoform
iodoformogen
iodole

pericarditis- see also, endocarditis

iodides
iodine

peritonitis

iodine

pharyngitis- see also, throat, sore, tonsillitis

iodine, iodoform
iodoformogen

phthisis- see also, cough, hemoptysis, hectic fever, perspiration, night sweats, laryngitis, tubercular, meningitis, peritonitis, etc

iodine: liniment as a counter-irritant to remove the consolidation in early stages, and to remove pain and cough later, as inhalation to lessen cough and expectoration.
iodine tincture
iodopin
iodoform: inhalation
iodole

uterine tumors

iodine

a sampling of iodine preparations found in the 1899 Merck Manual: