IODINE TEARS

image source- wiki commons

This is from an old detective story entitled "The Sorceress of the Strand- V. The Bloodstone.", found in "The Strand" Magazine, 1903. Apparently there were six parts in the Sorceress Tales.... More information can be found here:

http://prettysinister.blogspot.com

A synopsis: Lady Bouverie(Violet) is being framed for the theft of a treasured Persian Bloodstone. Madam Sara(the villian) dresses up and acts the part of a distraught Violet handing something over to a masked man and then dropping a handkerchief during a midnight liaison in a moonlit garden...

"He", referred to below, is Eric Vandeleur, Doctor, Madam Sara's arch-nemesis and, conveniently, an old family friend of Lady Bouvier's(and her treating physician)! "I", referred to below, is the detective, Dixon Druce, also conveniently an old family friend of Violet's.

How fortuitous that the major players would all end up in the mansion at the same time... !!

you can read the story in it's entirety here, it's actually quite entertaining:

The Sorceress in the Strand, Part V

Vandeleur's expression suddenly changed. He was regarding Lady Bouverie with a steady look; he then took up the handkerchief which we had found, examined it carefully, and laid it down again.

"Have you been taking the medicine I ordered you, Lady Bouverie ?" was his remark.

"I have," she replied

image source- wiki commons

"To-day?"

"Yes; three times."

"Will someone give me a large, clean sheet of white paper?"

I found one at once and brought it to him. He carefully rolled the handkerchief in it, drew out his stylograph, and wrote on the package :—

'' Handkerchief found by Sir John Bouverie and Mr. Druce at 12:40 a.m."

He then asked Lady Bouverie for the one which she had in her pocket; this was almost as wet as the one I had picked up. He put it in another packet, writing also upon the paper:—

"Handkerchief given to me by Lady Bouverie at 3:20 a.m."

Then, drawing the inspector aside, he whispered a few words to him which brought an exclamation of surprise from that officer.

"Now," he said, turning to Sir John, "I have done my business here for the present. I mean to return to London at once in my motorcar, and I shall take Mr. Druce with me. The inspector here has given me leave to take also these two handkerchiefs, on which I trust important evidence may hang."

He drew out his watch.

"It is now nearly half-past three," he said. "I shall reach my house at 4.30; the examination will take fifteen minutes; the result will be dispatched from Westminster police-station to the station here by telegram. You should receive it, Sir John, by 5.30, and I trust," he added, taking Lady Bouverie's hand, "it will mean your release, for that you are guilty I do not for a moment believe. In the meantime the police will remain here."

He caught-my arm, and two minutes later we were rushing through the night towards London.

"My dear fellow," I gasped, "explain yourself, for Heaven's sake. Is Violet innocent?"

"Wonderful luck," was his enigmatical answer. "I fancy Sara has over-acted this piece."

"You can find the bloodstone?"

"That I cannot tell you; my business is to clear Lady Bouverie. Don't talk, or we shall be wrecked."

He did not vouchsafe another remark till we stood together in his room, but he had driven the car like a madman.
He then drew out the two packets containing the handkerchiefs and began to make rapid chemical preparations.

"Now, listen," he said. "You know I am treating Lady Bouverie. The medicine I have been giving her happens to contain large doses of iodide of potassium. You may not be aware of it, but the drug is eliminated very largely by all the mucous membranes, and the lachrymal gland, which secretes the tears, plays a prominent part in this process. The sobbing female whom you are prepared to swear on oath was Lady Bouverie at the rendezvous by the summer-house dropped a handkerchief—this one." He laid his finger on the first of the two packets. "Now, if that woman was really Lady Bouverie, by analysis of the handkerchief I shall find, by means of a delicate test, distinct traces of iodine on it. If, however, it was not Lady Bouverie, but someone disguised with the utmost skill of an actress to represent her, not only physically, but with all the emotions of a distracted and guilty woman, even to the sobs and tears—then we shall not find iodine on the analysis of this handkerchief."

My jaw dropped as the meaning of his words broke upon me.

"Before testing, I will complete my little hypothesis by suggesting that the note, evidently thrown in your way, was to decoy you to be a witness of the scene, and that the handkerchief taken from Lady Bouverie's room and marked with her initials was intended to be the finishing touch in the chain of evidence against her. Now we will come to facts, and for all our sakes let us hope that my little theory is correct."
He set to work rapidly. At the end of some operations lasting several minutes he held up a test tube containing a clear solution.

"Now," he said, opening a bottle containing an opalescent liquid; "guilty or not guilty?"

He added a few drops from the bottle to the test tube. A long, deep chuckle came from his broad chest.

"Not a trace of it," he said. "Now for the handkerchief which I took from Lady Bouverie for a check experiment."

He added a few of the same drops to another tube. A bright violet colour spread through the liquid.

"There's iodine in that, you see. Not guilty, Druce."

A shout burst from my lips.

"Hush, my dear chap!" he pleaded. "Yes, it is very pretty. I am quite proud."

-I am impressed that the authors of this turn of the century detective story knew that iodine is eliminated, in part, by the lachrymal glands!

-and that they knew of the iodine starch test :)

The Evil Madam Sara posing as Lady Violet in the Moonlit Garden...

The Iodine Drinkers

A treasured possession :)

A dark time in the history of iodine would be the the time of the "Iodine Suicides".  A spate of "Iodine Drinkers" were documented in the popular media. These "iodine drinkers" were mostly young women, conceivably because of the reputation for "hysteria" that women had(have), especially young women. And, as so eloquently stated in the Time Magazine article cited, "young women are at home, near a medicine cabinet, most of the time".

Prior to this time the necessity of iodine, and iodine's reputation as a cure-all was firmly established in  mass consciousness. 

After this time, and to this day, the idea that iodine is "poison" is an idea that we must argue. It's not the iodine, after all, it's the denatured alcohol in the tincture. IODINE IS ESSENTIAL.


Girl Visitor Drinks Iodine

Tells Chinatown Sightseers That She is Penniless and Wants to Die

Iodine Tincture Poison Label

Screaming that she had drunk Iodine, a well dressed young woman who said she was Miss Evelyn Smith, 21 old, of 321 west Fayette Street, Baltimore, MD., fell to the sidewalk in front of the Chinatown Joss House in Mott Street last night, and then begged about 100 sightseers who ran to her assistance to let her die. She was taken to Volunteer Hospital, where it was said her condition was critical.

Miss Smith told the police she had come here on Friday from Baltimore on a truck, penniless, had walked the streets Friday night and had had no sleep.

In her pocket was a note to her mother, Mrs. George Smith, 642 Madison Avenue, Montreal, Quebec, Canada, begging forgiveness after saying she was sorry she could not see her before dying. She said her mother was an actress.

Miss Smith would give no reason for her desire to die.

The New York Times, published November 7, 1920

Girl Visitor Drinks Iodine

image source, wiki commons

SCOLDED, SHE DRINKS IODINE

Fights Doctor and Policemen Who Come to Her Rescue

Mary Gibbs, 14 years old, attempted suicide by drinking iodine in the bathroom of her home at 535 West 134th Street last night because her mother scolded her. She fought a policeman and a doctor who tried to use a stomach pump, but her resistance was overcome, and she was taken to Lincoln Hospital. She will recover.

The girl went to a store near her home last night and her mother found that she had made a mistake in changing a bill. Resenting her mother's scolding, Mary drank nearly a bottle of iodine. Her brother John, 8 years old, heard her fall and told Mrs. Gibbs who summoned help.

The New York Times, published December 28, 1922

Scolded, She Drinks Iodine



TAKES POISON IN CHURCH

Girl's Screams After Drinking Iodine Startle Holy Trinity Parishioners

image source, wiki commons

Parishioners of Holy Trinity Church, 205 West Eighty-second Street, who had gone to confession last evening at 6 o'clock, were startled by the screams of a young woman who fell to the floor just as she stepped through the door from the vestibule. Several persons, including the priests, ran to her aid.

"I have swallowed IODINE." she gasped.

One of the parishioners ran to the office of Dr. Clarence J. D'alton, 203 West Eighty-first Street and returned with the physician. He administered first aid and an ambulance was summoned from Knickerbocker Hospital. The young woman said she was Mary Neary, 22 years, of 208 West Sixty-seventh Street. S he refused to tell why she had drunk the poison. She was removed to the hospital, where it was reported that her condition was not serious.

The New York Times, published January 23, 1921

Takes Poison in Church


"Tired of Life", Tries to Die

image source, wiki commons

Girl Collapses After Taking Iodine, But Will Recover.

She was "tired of Life" was the explanation yesterday morning by Katie Cavanaugh, 25 years old, of 641 Tenth avenue, for mixing iodine with a widely advertised nerve tonic she had just purchased at a soda fountain on Eighth Avenue, near Forty-seventh Street.

The young woman collapsed in the street and was removed to Bellevue Hospital. It was found that the dose had been small and that she probably would live.

The New York Times, published August 7, 1922

Tired of Life, Tries to Die


GIRL FOUND POISONED

image source, wiki commons

Sailors Rescue Sufferer from IODINE on Riverside Drive

The screams of May Mantone, 19, of 242 West 109th Street, on the sloping lawn on Riverside Drive at 109th Street, brought to her aid two sailors, William Straw and Edwin Johnson. With the assistance of Donald Freeman, a Columbia student, she was taken to a drug store at Broadway and 107th Street, where first aid for iodine poisoning was given.
An ambulance from the Harlem Hospital was summoned and Dr. Buchman took her to the hospital unconscious. Neighbors said that the girl lived with her father and a sister but both father and sister were away last night. 

The New York Times, published March 13, 1922

Girl Found Poisoned

And finally, an article from Time Magazine, 1938, that attempts to explain the iodine suicide phenomena...

Iodine Suicides

Young Dr. Merrill Moore of Boston is known as a psychiatrist, semiprofessional swimmer and author of 25,000 good and bad sonnets. With all his zest for life, Dr. Moore is most interested in the problem of suicide, has collected many scientific facts on this phenomenon. Last week in The New England Journal of Medicine he discussed the agent most commonly used by would-be suicides: iodine.

Although the years 1915-36 showed a steady increase in the number of iodine drinkers, said Dr. Moore, not one fatal case of iodine poisoning was observed in Boston and vicinity. Reasons: 1) Iodine cannot be absorbed by the body without chemical change. It combines with fatty acids, proteins, starches, or unites with another element and changes from a powerful, slow-acting cell poison to a less toxic iodide. 2) Iodine produces such intense irritation of the gastrointestinal tract that the stomach rejects even small amounts.

Only a heroic dose will result in death, and when death does occur it is usually due to overstimulation of the thyroid.

3) Many people purposely take only a small amount since "iodine is used chiefly by essentially immature persons at ages when they have failed to gain attention and satisfaction and bid for these by sensational means." Largest group of iodine drinkers, added Dr. Moore, are females between 14 and 20 (they are home near a medicine cabinet most of the time). Largest group of males are between 26 and 30. Whether they know that an ordinary gulp of iodine is seldom fatal, Dr. Moore could not say. He inclined to think not, however, since druggists glue a suggestive skull and bones to every iodine bottle.

Iodine Suicides, 1938

Iodine gets the lead out

Unusual Case of Lead Poisoning.—Three months before the onset of foot drop, the patient had suffered an attack of lobar pneumonia and had been very ill. Many years previous to this, he had had occasional attacks of "rheumatism.'' With the exception of the rheumatism he had not been ill for 16 years. This sickness had been an unusually severe attack of lead poisoning which he had developed while working "in a sheet lead factory" where he had been foreman. After repeated attempts to continue his work there he had been obliged to resign a very lucrative position and discontinue this kind of work. He had had "colic" so severely that the physician in charge had despaired of his life and had expected him to die. Recovery had been tedious and he had never been well since. Still in the last years he had not shown symptoms of lead poisoning and had considered his ill health clue to rheumatism.

It was difficult to imagine this present foot drop to be directly clue to "leading" sixteen years ago, and the history of his past illness was again reviewed. Special inquiry was made of the attack of pneumonia, which condition the present trouble has so closely followed. Apparently he had had a frank attack of lobar pneumonia but said that the physician in charge thought the lung had not returned to its normal erudition, and that he had taken medicine for some time after he was up and about. He was asked to describe this medicine which he did as follows: "The medicine was bitter drops, made my nose run as though I had the hay fever, and I took ten drops after each meal. The medicine formed a white scum over the neck of the bottle and turned the label brown." The explanation of the case seemed clear to Lazell. The lead deposited sixteen years before in some insoluble form in the bones, had been thrown into solution by the iodids given for an unresolved pneumonia and acute lead poisoning had resulted. The patient was given a good prognosis, saturated with sodium iodide and made a complete recovery. 1

____________________


In many forms of chronic rheumatism, and in certain affections of the osseous system, due to a syphilitic taint, iodide of potassium is of the greatest service; and its value in the treatment of chronic lead-poisoning is not so generally known, even in the medical profession, as it deserves to be. The iodide of potassium dissolves the compounds of lead with albumen, fibrine, fcc, which abound in the body in chronic lead-poisoning; and these dissolved compounds are excreted by the kidneys. In these cases, lead may often be detected in the urine, almost immediately after the administration of the iodide. This salt has a similar action in chronic mercurial poisoning, and cases are recorded of mercurial salivation having come on during the use of iodide of potassium, in consequence of the liberation of mercury, which had been previously fixed in the system. 2

1 The Journal of the American Medical Association. Volume 55, 1910

2  Chambers's Encyclopaedia, Volume V, 1931

Iodism and eliminative function

Another article on syphilis. Good advice, though on how to avoid "iodism".

The general hygienic management of syphilis is of fundamental importance. In many instances mercury and iodides act badly, simply because the patient's eliminative areas are not functionating with their normal activity. Injurious results from the drug specifics occur under such circumstances, and are explained by that explanation which does not explain, "idiosyncrasy." Ptyalism and iodism may both be avoided in many cases by attention to the eliminative functions. The ingestion of large quantities of water, with the concomitant increased functional activity of the skin, kidneys and bowels, is very useful in syphilis. This point is too frequently neglected. In giving iodides it is best, as is generally known, to administer them simultaneously with considerable quantities of water. It is impossible, however, without resulting stomachic disturbance, to give a sufficient quantity of water in this way to perfect elimination by the kidneys in certain cases in which the renal function is inadequate. It is in just such cases that iodism from so-called idiosyncrasy is liable to occur.

The best method of giving the iodide under such circumstances is to mix the daily dose of the drug with a given quantity of pure water, say from two quarts to a gallon, and instruct the patient to drink the entire amount, a glassful at a time, at intervals during the twenty-four hours,  have succeeded in avoiding iodism in this way in patients in whom the smallest quantity of iodide given by the ordinary method produced iodism.

Hot baths are a very useful adjuvant to the treatment of syphilis. They increase tissue metamorphosis, favor; elimination, and necessarily enhance the therapeutic action of the mercury and iodide, while limiting any possible injurious effects of the drugs. In many instances hot baths alone will prevent injurious effects from mercury and iodide. A very hot bath of short duration, taken daily and followed by a cold shower or cold tub, is perhaps the best method of administration for the average patient. The ideal method, however, where its application is practicable, is the Turkish or Russian bath. The patient should drink large quantities of hot water while in the bath. Much of the efficacy of the Hot Springs treatment of syphilis is dependent upon the free ingestion of hot water while the hot bath is being given.
Attention to the bowels is very important in the treatment of syphilis. Ptyalism not infrequently results as a consequence of constipation. Obviously, the simpler forms of laxatives are best. The saline aperients taken hot in the morning are excellent. 

Ptyalism~ an excessive flow of saliva.

  The Medical News, Volume 80, 1902

GENERAL MEDICAL TREATMENT OF SYPHILIS.

BY G. FRANK LYDSTON, M.D., 

           of Chicago; 

PROFESSOR Of GENITO-URINARY SURGERY AND SYPHILOLOGY IN THE 

   MEDICAL DEPARTMENT OF THE UNIVERSITY OF ILLINOIS; PRO- 

      FESSOR OF SURGERY IN THE CHICAGO CLINICAL SCHOOL. 

THE SIMULTANEOUS OCCURRENCE OF TUMORS IN THE THYROID, UTERUS AND BREAST

THE SIMULTANEOUS OCCURRENCE OF TUMORS IN THE THYROID, UTERUS AND BREAST

MAX BALLIN, M.D. AND R. C. MOEHLIG, M.D.

DETROIT

article source: Journal of the American Medical Association, 1922


________________________________________________________________________________


Every surgeon who operates upon goiters must have noticed the frequent occurrence of tumors in the thyroid, uterus and breast. Apparently there has been very little written on the subject, however, for we could find only two references in the literature. Falta's 1 "Ductless Glandular Diseases" contains this note:

"There seems to exist a certain relationship between goiter and myomata of the uterus. At least it has been observed that in strumous women who also suffer from myomata the struma also decreases in size with the retrogression of the myoma at the menopause."

Falta's note is quoted from an article by Ullman 2  of Vienna. This article reads:

 thyroid gland

It has been known for a long time that a relationship exists between the uterus and the normal thyroid gland. The nature of this relationship is, of course, enshrouded in darkness; we only know that in a not infrequent number of women a transitory enlargement of the thyroid gland takes place at the time of menstruation. After the cessation of menstruation, the thyroid returns to normal. ... In many women during pregnancy an enlargement of the thyroid takes place, which still exists after childbirth. ... A third fact which concerns the question of the relationship between uterus and thyroid is that as to whether strumas develop more frequently in females then in males. ... I wish to emphasize that in women affected with myomas I was able to show a distinct enlargement of the thyroid gland, an enlargement that could be spoken of partly as struma parenchymatosa, partly as the result of degeneration, as colloid struma. ... I was then able to determine that these strumas following complete myomectomy became decidedly smaller; in many cases they disappeared entirely.

1. Falta, Wilhelm: Ductless Glandular Diseases, Philadelphia, P. Blakiston's Son & Co., 1916, p. 156.

2. Ullman. Emmerich: Ueher Uterusmyom and Kropf, Wicn. ktin. Wchnschr. 23: 58S, 1910.

In looking over our own records, we find that of the last 100 female patients who consulted us for goiter, eighteen had fibroids;  four of them also had breast tumors; and of the last 100 patients who consulted us for fibroids, thirty-five had goiter; six had breast tumors. Thus, of the total 200 patients, fifty-three, or 26.5 per cent., had tumors of both thyroid and uterus. Ten of these 200 patients required operations on both the thyroid and the uterus. This large number of multiple lesions is obviously much more than a coincidence; yet, as noted above, very little mention of it has been made.

The matter therefore seemed important enough to call attention to again. Three points suggest themselves:

(a) It is possible, as suggested by Ullman, that certain goiters might be reduced in size or even cured by removal of a fibroid.

(b) Thyroid extract and iodin might be beneficial in preventing the development of fibroids as well as of goiters.

(c) These relationships might have some bearing on the etiology of these tumor groups.

fibrocystic breast tissue

In the eighteen goiters found in the examination of 100 fibroids, fourteen were adenomas of the thyroid, three were colloid goiters, and one was an exophthalmic goiter. Of the four breast tumors which accompanied goiters, an adenofibroma with cyst-areas accompanied an adenomatous goiter; an adenoma of the left breast accompanied an adenomatous goiter; an intracanalicular adenofibroma in the right breast, and a similar tumor with hyaline changes in the left breast accompanied a colloid adenomatous goiter. Another goiter which is not tabulated showed virginal hypertrophy of the right breast. Of the six breast tumors which accompanied fibroids, three were interstitial mastitis; one was a fibro-adenoma; one was a carcinoma of the left breast and fibro-adenoma of the right breast, and one was a cystadenoma.

uterine fibroids

Of the fifty-three patients with the combination of goiter and fibroid, the youngest was 25 years old, this patient being the only one below 30. Fully two thirds were over 35. We may say, therefore, that the incidence mounts with age, the simultaneous occurrence of goiter and fibroid being most prevalent in the latter half of the third decade and during the fourth decade. Of the 100 goiter patients, twenty-one were under the age of 25. There were no fibroids among these patients, so that the percentage of eighteen fibroids is borne by seventy-nine patients more than 25 years of age. In other words, the fibroid-goiter combination shows its entire incidence after 25 years of age, and increases rapidly after 35 years.

The simultaneous occurrence of goiters, fibroids and breast tumors is more frequent than is usually supposed. The thyroid, breast and uterus have different anatomic structures and are different in their embryologic origins, but we note that the function of the thyroid is closely related to, and influences the function of the sexual organs. The interrelationship of uterus and breast is obvious. Since these organs are related to each other only by function, it must be that physiologic interdependence is a factor in the tumor formation.

normal breast tissue

When sexual function ceases or begins to wane, usually the time arises for the growth of all these

tumors. The symptoms of fibroids usually become more alarming toward the end of the reproductive period. The adenomatous goiter, in the great majority of cases, does not give much discomfort until the menopause. Then pressure and toxic symptoms arise. Small tumors in the breast have often existed from the age of 20 to the age of 40 without giving any symptoms, or without having been noticed at all; still, their long-standing existence usually is clear when their presence becomes obvious through growth or discomfort. Because of the aforementioned functional (physiologic) relationship which exists between thyroid, uterus and breast, we may be able to understand why growth or irritation in one of these organs may induce growth or irritation in another. For instance, when a small fibroid which has existed innocently for many years suddenly begins to grow, it may induce growth or irritation in the thyroid or breast (and vice versa).


CONCLUSIONS:


1. In a series of 200 cases (100 fibroids and 100 goiters), fifty-three patients, or 26.5 per cent., had both goiter and fibroid. Five per cent, had breast tumors.

2. The age of incidence of these combinations was greatest after 35.

3. Since these three organs are not related anatomically or embryologically, the simultaneous occurrence of tumors in the thyroid, uterus and breast may be explained by their physiologic interrelationship.

4. The prophylactic treatment now advocated, of giving iodids for goiter, may likewise prove beneficial in the prevention of fibroid.

5. Perhaps certain goiters can be reduced in size or even cured by the removal of a fibroid (as suggested by Ullman).

all images- wiki commons

Toxic Breasts

BENIGN MAMMARY TUMORS AND INTESTINAL TOXEMIA*
By William Seaman Bainbridge


•Read at the Thirty-third Annual Meeting of the American Association of Obstetricians, Gynecologists, and Abdominal Surgeons, held at Atlantic City, N. J., September 20-22, 1920.


Wow, just wow. It seemed to be well-known, back in the day, that digestion was key. This physician cured lumpy breasts with adjustments in diet, laxatives, colonic irrigation and enemas. He also cured the condition with various surgeries, occasionally removing cysts but in the majority of cases the surgery was abdominal, removing adhesions and generally rearranging the organs and such. I have chosen to include only those cases that were cured by hygienic methods, if you wish you can follow this link and read all about the cases which required surgery:


American Journal of Obstetrics and gynecology, Volume 1



 It is worth noting that Dr. Bainbridge was able to save women's breasts via these abdominal surgeries, in fact saving breasts that had been deemed cancerous by other physicians.







The present paper purposes to record a series of twenty-five eases of abnormal mammary changes apparently caused by autointoxication. When these cases are seen in their early stages the breast condition is often overlooked; when they have developed into a more easily recognized state, frequently a diagnosis of malignant disease is made.


Each of the cases reported herein suffered from a coexistant chronic intestinal toxemia, and the amount of poisoning was reflected, in many instances, in the degree of change in the mammary tissue. When the autointoxication was relieved the breasts either markedly improved or returned entirely to the normal.


These cases classify themselves, more or less, into three groups. 1. Those with a condensation or lobular induration of the upper, outer quadrants of the breasts, usually along the edge of the large pectoral muscle, and where the dependent breast drags on the upper axillary margin. This occurs in both mammae, but more frequently in the left. Such terms as "toxic breasts," "lumpy breasts" or "stasis lumps" are descriptive of this condition. 2. Those cases that have, in addition to the above, and in the same region, localized degeneration with adenomata or cystomata. 3. Those that have an abnormal discharge from the nipple in conjunction with one or the other of the above conditions.


The diminishing of the gastrointestinal fermentation by diet, digestives, intestinal antiseptics, high alkaline colonic irrigations, and certain physiotherapeutic measures, is of distinct value. The use of these agents, together with a support to the breasts and a proper uplifting abdominal corset, often result in a complete disappearance of the breast lumps or tumors. However, some of the cases require surgical intervention of the underlying abdominal condition before the toxic poisoning is sufficiently relieved as to noticeably benefit the breasts.


In those cases where there is a cyst or adenoma in addition to a general lobular condition of the breasts, the removal of the growth and the correction of the intestinal stasis, by medical or surgical means, often result in the mammae becoming completely normal. A preliminary lessening of the general toxic condition, in some cases, materially helped in locating the real existing benign neoplasm, and hence it was made possible to save a considerable amount of curable breast tissue. By this means the patients were saved the mental and physical shock of an unnecessary amputation.


Case 1.—I. I.; age thirty-five; female; single. First seen May 12, 1919. Constipation with usual symptoms of intestinal stasis; backache. On examination, found floating right kidney; general enteroptosis; mass of feces in lower colon; considerable gas in ascending and transverse colon; marked lumpy condition in upper, outer quadrant left breast. Prescribed tonic, laxatives, uplifting corset belt; special abdominal exercises, and general hygienic regime. June, 1920: Patient in excellent health; constipation relieved; no longer any lumps in breast. September 1920, passed examination to enter training school for nurses of large metropolitan hospital.


Case 2.—E. S.; age thirty-three; female; single. First seen September, 1898. Marked constipation; frequent attacks of intestinal gas; distinct lumps in upper, outer quadrant of left breast; nipple normal. Very much worried about cancer. Prescribed diet, cathartics, and support to breasts, with very careful and frequent examination. Six months after treatment was begun lumps in breasts disappeared. For some years, patient noticed that if she became constipated and had "indigestion," there was a return of the lumpy condition. This was relieved by thorough catharsis. August, 1920: Breasts perfectly normal.



Case 3.—J. L.; age thirty; female; single. First seen January, 1919. Subacute attack of rheumatic fever; feet extremely swollen; painful; intestinal indigestion; headaches; nausea; marked constipation. On examination found intestinal stasis; large lumps in both breasts; enlarged glands of neck; swelling of feet and ankles. Prescribed diet; high alkaline colonic irrigations; salicylates, for a short time, cathartics, with physiotherapy as able to take it. September 1920: Under treatment, swelling and pain in joints of feet and elsewhere gradually disappared. Lumps in breasts entirely gone after two months. Twice she allowed herself to become constipated and to be indiscreet with diet and at both times noticed a soreness and distinct lumpy condition of breasts, which disappeared upon resorting to careful treatment.

Case 4.—W. R.; age twenty-eight; female; married. First seen November 27, 1906. Rectal abscess and cyst of perineum removed. In 1919 complained of intestinal gas; loss of weight; constipation; soreness of breasts, worried about cancer. On examination, found gastroptosis; ascending colon and hepatic flexure clogged with fecal matter; considerable gas; distinct lumpy condition throughout breasts, more marked in upper, outer quadrant. Prescribed abdominal and breast supports; laxatives; high alkaline colonic irrigations several times a week; diet; tonic; special exercise. June, 1920: Patient stated she was no longer a "nervous wreck"; when careful of diet and bowels there is no soreness in breasts. Considers herself well. August, 1920: Excellent condition; breasts normal.

Case 5.—A. G.; age forty-eight years; female; married. First seen December 9, 1918. Complained of pain and discomfort in left breast. On examination, found breasts very large, dependent, and the inner quadrant of left one slightly lobulated; no real tumor formation. Prescribed breast support; laxatives, with usual hygienic regime and careful watching. June, 1920: Lumpy condition of breasts entirely relieved—still a little soreness; constipation improved.

*********************************************************************************

SUMMARY

1. There are definite abnormal changes in the breast tissue, as in the thyroid gland, from intestinal toxemia.

2. Treatment by medical and mechanical means, or surgical intervention for the cure of the intestinal stasis, often means complete return to the normal of the lumpy or toxic breasts.

3. At times it is necessary to remove a definite, localized tumor from the breast, in addition to the above, before the mammary tissue regains its normal texture.

4. Care must be taken that these abnormal changes are not overlooked in their early stages; and not diagnosticated as cancer when well developed.

5. In this connection, an important question must be noted: Would an early recognition of a toxic breast and timely and efficient treatment of the underlying intestinal causes, tend to lessen the danger of malignant degeneration? If this is so, then we have here an important contributory factor in the etiology of cancer of the breast.

Iodine Bread- Kelpin Bread!

"Have your daily helpin' of that kelpin!" 

~ Haha, I should have been a copywriter for these folks...

The first three photos are a section from an advertisement for Kelpin Bread. The following photos are all full advertisements, all gleaned from Google News archives, from newspapers circa 1930 and 1931. 

I wish I knew how to remove the search highlighting, I don't. !

iodine for grace and beauty!

iodine prevents goiter!

9 slices of bread!? yikes!

iodine makes you slender!

iodine prevents heart trouble and nervousness!

"drug iodine" *sigh*

kelpin RULES!

kelpin for VIGOR!

iodine makes you RUGGED!

Iodine rules~

Tincture Of Iodine As A Surgical Antiseptic. April 11, 1911

alternate post title~ "Iodine or Amputation?"

source: "Boston medical and surgical journal, Volume 164, Issue 2", 

  PARIS LETTER.


Tincture Of Iodine As A Surgical Antiseptic.


~From Our Special Correspondent


Paris, April 11, 1911.

Mr. Editor: One of the most surprised preparations in materia medica at the present moment must be our timehonored acquaintance, the tincture of iodine, and there is no gainsaying the fact that it has sufficient grounds for a meditation on the uncertainty of the things of this world. During all the earlier half of the last century this familiar reddish-brown liquid was one of the most important remedies in medical practice, so much so that in 1855 a certain Boinet published a large volume of eight hundred and thirty-five pages about it, entitled "Trait d' Iodotherapie." Already at that time its remarkable antiseptic properties had been noted; fetid pus had been seen to lose its noxious qualities under its influence, and compound fractures had been found to heal without any of the terrible complications so frequent in those times when treated with tincture of iodine. In a word, it seems as though at that period the antiseptic era was on the point of being discovered, in connection with this preparation, some twenty years before the Pasteur-Lister day. The opportunity was there; all that lacked, apparently, was the man with sufficient perspicacity to descry the great discovery that was staring him in the face. That man, however, was not forthcoming. The reign of phenol, sublimate, formal and peroxide began, iodine tincture was practically relegated to the old woman's arsenal, and this marvelous preparation descended very nearly to the level of arnica and chamomile tea!


This period of oblivion lasted for nearly forty years, but now, by the agency of one of those disconcerting turns of the wheel of fortune, tincture of iodine has once more been raised to a position of real eminence in medicine, and suddenly — within the brief space of a couple of years. In this short time it has not only regained the rank in the medical world that it ought never to have lost, but its penetration into the masses has been so deep that it has attained even to such remote regions as the cerebral substance of society women. One of them got her finger-end caught in the door of her carriage the other day and gave it a pretty lively squeeze, producing a small wound par eclatement. When I arrived I remarked in scornful tones, "What in the world did you put arnica on it for?" She was generous in her triumph, that I must allow; for of course she had a lovely chance to make some withering reply. All she said was, "Oh no! that isn't arnica; I drove to the nearest druggist and had the finger painted with iodine!" "The devil you did," thought I; "if these Red Cross lectures continue to rage throughout the land, the future of the medical profession will soon be even less roseate than it seems at present. For the idea is to me not inconceivable that within a delay that is really more or less proximate, the physician is going to have to make his choice between some of the side-branches of his calling, — electricity, radium, x-rays, or mind-treatment, — or harakiri after the scorpion method. Certainly if I had a son who was going in for general medicine, the utmost degree of sympathy at my disposal would be extended toward him, as I think he will see the time when his profession will no longer be a living proposition.


Tincture of iodine, then, has been discovered to be the most marvelous antiseptic known, and, — details that enhance its virtues many times over, — one whose use is simplicity itself, that can be found anywhere and that can be safely put into almost any one's hands. From one point of view it has a similarity with salvarsan in that it is of particular use in very difficult cases, cases that proved almost beyond the resources formerly at our disposal. This will be referred to in a moment; for the present let me cite an instance or two that have come to my ears recently.


One of the younger surgeons here received an urgency call the other day to come at once to such and such a hospital for an amputation. When he arrived he found a man who had got his right hand badly crushed in handling wine barrels, with various fractured bones and wounds, the whole region being, of course, as dirty as possible. It had never occurred to the interne that any other treatment than amputation or disarticulation was to be considered; yet, with simple iodine paintings, this man made a perfect recovery with a quite serviceable hand.


Another surgeon friend of mine went one afternoon to see a lady patient on whom he had operated a short time previously for appendicitis. She told him that her last monthly period had missed entirely and that she was now feeling considerable pain in the pelvis. On examination he found a small mass back and to one side of the uterus, diagnosed extra-uterine pregnancy and told her she must have it removed without delay. That same; evening at ten o'clock he was called to see her again; pain had increased and her condition and appearance had alarmed those about her. The fetal cyst had evidently ruptured during the evening, the patient presented all the signs of serious internal hemorrhage and my surgical friend found himself in presence of as serious an emergency case as any one need desire, as it is not easy in Paris to get anything done in a hurry. However, by dint of heating up the telephone wires he managed to get the patient transported to a clinic and his aids assembled by one o'clock. By that time his unfortunate patient's condition was highly critical, the bleeding was evidently continuing and there was no time to lose. It is easy to conceive that with the former methods of preparing an abdomen for laparotomy, the loss of time, combined with the rough handling necessary to throughly brush and scrub the skin, might have given tliis patient the finishing touch, whereas in this instance, while the surgeon was slipping on his sterilized India-rubber gloves, the assistant simply painted the abdominal surface gently with soft gauze dipped in tincture of iodine and held in a forceps, there was not the slightest delay or mauling of the patient a rapid incision revealed an abdominal cavity filled with blood, the cyst was clamped at once, the usual means of treating severe loss of blood could then be brought to bear, and the surgeon was master of the situation. Such a case as this must, I think, be one of the surgeon's keenest satisfactions, a case in which he is authorized to feel that but for his intervention his patient would have succumbed without doubt in another hour or two. This same man operated an umbilical hernia in a dog for me the other day with the iodine process without even shaving the region; it seems that this is current practice in the experimental laboratories now.


The iodine tincture of the French pharmacies is a one in ten solution in alcohol. It should, whenever possible, be procured fresh; when old it is subject to two secondary processes whereby it becomes stronger and more likely to irritate: the development of hydriodic acid, and concentration through alcohol evaporation. The question is being studied whether it is really necessary to use this one-tenth solution; whether, for instance, this could hot equally well be further extended with alcohol to at least one-twentieth, or whether aqueous solutions obtained with iodide will not be just as efficacious.


 For although it has proved to be one of the safest of all antiseptics, we all know that there are certain patients with a marked idiosyncrasy for iodine with whom small doses produce the most alarming symptoms, and in particular those of edema of the glottis. Thus in the case in point I personally have heard of one patient with whom a most distressing and persistent generalized eczema was brought on by a single application of tincture of iodine; and of another who actually succumbed from acute iodism under the same circumstances. Because, not only is the iodine being applied on normal surfaces, as in the above extra-uterine pregnancy case, or as has been done by different surgeons in emergencies when away from all facilities and they have painted their own hands in order to operate; and not only is it used on open and crushed wounds, and even on extensive denuded surfaces such as burns, but it is applied to severe solutions of continuity, such as a scythe wound, the surfaces being stitched together a few minutes later, and it is also injected into suppurating cavities or fistulas. Under these circumstances a certain amount of the iodine must remain behind; so that if an equal effect can be obtained by a less active solution, it is certainly to be desired that this point should be demonst rated as quickly as possible.
There is a trifling artifice that it is useful to know, in order to have it at one's disposal in instances when a modicum of mind-cure is necessary. Certain families keep tincture of iodine in stock and use it themselves on all occasions, just as others do their precious Pond's Extract or Antiphlogistine. One woman I know here gets Pond's Extract over from America by the demijohn, and has the most absolute faith in its virtues to cure nearly every affection her large household of family and servants presents. To prescribe to such a person a remedy that she is in the habit of using herself would simply be to lose caste in a very precipitous fashion; whereas if you sit down and gravely formulate:

 Metalloidic iodine, 3

   Spirits of chloroform, 30

the effect will be magical, as the druggist will sent her a beautiful cerulean blue solution which you caution her to apply with great care as it is very active, whereas it is in reality nothing but the familiar old one in ten tincture of iodine!


A point that I have been turning over in my mind is whether this preparation may not be excellent for medical use, and in particular for tonsillar affections. The peculiar efficacy of iodine tincture is said to be due to its marked power of penetration, which in turn depends on its alcoholic vehicle; to be really efficacious, then, it should be applied to a perfectly dry surface, all previous cleansing by washing, soaping, etc., impeding its action. Now in the throat a dry surface could scarcely be obtained; but by first carefully wiping off the tonsillar region something approaching such a condition could be produced; besides, the tonsil is not protected by any hard layer of epidermis. I have often used in the throat a preparation consisting in one part of tincture of iodine to two of glycerine, but have never been able to see that it accomplishes very much. This is perhaps due to a peculiarity that we find in phenol, which seems to lose many of its properties, causticity, toxicity, etc., when combined with glycerine. It will be interesting to see how the tonsil reacts to pure tincture of iodine without the glycerine.


I remarked above that the tincture of iodine is particularly effective in the very worst cases, and the type of these is the mechanic or train-hand, who gets one of his extremities mashed in the course of his work. Not only do these accidents present the very worst forms of lesions, — mangled and torn tissues, open articulations and compound fractures;—but the damaged region cannot be otherwise than in the filthiest possible condition. These cases, also, are generally somewhat long in getting to the nearest help, particularly in a railroad accident out on the line. It has really seemed to me worse than useless to attempt to clean up such an affair as a mechanic's hand mashed in a machine. Will not the cleaning send into the open wounds more germs than are there already? My surgical friend assures me that by filling up all the wounds with strips of sterile cotton soaked in some antiseptic fluid, and then operating with care, patience and benzine, the thing can be accomplished; so I suppose we shall have to take his word for it. But however this may be, all doubts of the sort are removed with the iodine process. Here, the less you do the better. No cleaning at all; at the most remove fragments that are bound to go any how, and be chary about this, for I think that the longer we live the greater becomes our respect for what nature can do at a push, then paint everything, — skin wounds, fractures, — carefully with the tincture, not being afraid to go over a surface more than once, and pushing it into every nook and hole. Over that, chiffonmr a lot of light gauze, then some cotton-wool, and a bandage, and the trick is done. 


Nothing simpler could possibly be desired, and a Trousse of this sort, with brief directions, could easily be on every train and in every factory. Strange to say, the pain connected with the application is really insignificant; it can be spread over large burns with equal results. Fancy the revolution this process is going to effect in first-aid ambulances near the firing-line in war time!


What happens, then, after such a dressing as this? The tincture appears to give rise to a profuse serous discharge, which is taken up by the chiffonnee gauze, which must not be protected by any hermetic tissue. Usually such a first dressing can be left in place for twentyfour hours, though of course, if the discharge soaks through the gauze, this can always be removed, and as often as desired. The next day the dressing is changed and the tincture applied again. This daily change is continued so long as the discharge lasts, which is, as a rule, from four to five days. The surfaces then become dry and the dressing and painting need only be done every three or four days.


The cases of recovery that have been reported under this treatment sound really more like fairy tales than serious surgical work. What do you think, for instance, of a compound, comminuted fracture of the leg that had been carefully cleaned, reduced and sewed up by a surgeon, but when his effects failed lamentably and gangrene set in, this was opened by another man, thoroughly painted in every corner, and recovered!


~"S"